| Title: | Association of Habitual Glucosamine Use with Cardiovascular Disease among Individuals with Prediabetes and Diabetes: A Prospective Cohort Study from the UK Biobank. |
| Journal: | Journal of Alternative and Complementary Medicine |
| Published: | 19 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41712318/ |
| DOI: | https://doi.org/10.1177/27683605261418094 |
Publication 17698
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Abstract
BACKGROUND: Compelling research has indicated that habitual glucosamine use was related to lower risks of cardiovascular disease (CVD) events. However, whether the inverse association is still valid in individuals with diabetes, who take on greater risk of CVD, remains unknown. Therefore, we aimed to examine the association between habitual glucosamine use and CVD in patients with prediabetes and diabetes.</p>
METHODS: This cohort study included 54,096 participants with glucosamine use information identified from the UK Biobank. Cox regression was used to assess the association of habitual glucosamine use with total CVD events and CVD subtypes in the population with diabetes and prediabetes. We also evaluated the combined impact of C-reactive protein (CRP) level and genetic susceptibility on heart failure, ischemic heart disease (IHD), and stroke.</p>
RESULTS: During a median follow-up of 10.56 years, 30,716 cases of overall CVD events were ascertained. We found significant inverse associations between glucosamine use and risk of CVD events among participants with diabetes and prediabetes (overall CVD events: hazard ratio, 0.94 [95%confidence interval: 0.91-0.96]; heart failure: 0.89 [0.81-0.99]; IHD: 0.89 [0.84-0.95], and stroke: 0.86 [0.77-0.97]). The effect of glucosamine on CVD was more pronounced in individuals with low CRP levels (0.85 [0.82-0.89]). Compared with individuals with high genetic risk and not-using glucosamine, glucosamine users with low genetic risk (heart failure: 0.64 [0.52-0.80]; IHD: 0.48 [0.42-0.55]) exhibited the lowest risks of corresponding CVD events.</p>
CONCLUSION: Habitual glucosamine use was associated with lower risks of CVD events in the population with diabetes and prediabetes. The association was more pronounced in individuals with low CRP level and low CVD polygenic risk score level, which helps us to identify the target population more suitable for glucosamine use.</p>
6 Authors
- Zhixuan Zhang
- Yahang Liu
- Lulu Pan
- Chen Huang
- Yongfu Yu
- Guoyou Qin
1 Application
| Application ID | Title |
|---|---|
| 96511 | Investigating the genome-wide association and risk factors for multi-organ ageing |
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