: Publication 17695

Publication 17695

Title:	Dietary inflammatory index in relation to incident CKD: A prospective study of UK Biobank participants.
Journal:	PLOS ONE
Published:	20 Feb 2026
Pubmed:	https://pubmed.ncbi.nlm.nih.gov/41719323/
DOI:	https://doi.org/10.1371/journal.pone.0341502
URL:	http://dx.doi.org/10.1371/journal.pone.0341502

Abstract

BACKGROUND AND OBJECTIVES: The relationship between increased inflammatory diet patterns and chronic kidney disease (CKD) remains unknown and has not been investigated in large cohorts.</p>

METHODS: A total of 154,070 adults registered in UKB database were enrolled and followed, free of CKD and eGFR > 90 mL/min/1.73 m2 at baseline. The energy-adjusted dietary inflammatory index (E-DII) was evaluated using the 24-h recall diet. Cox proportional hazards regression models were used, adjusting for confounders such as demographic indicators, socioeconomic status, and lifestyle factors. Additionally, a subgroup analysis was conducted to investigate the relationship with incident CKD. The nonlinear relationship between E-DII and CKD risk was analyzed using a restricted cubic spline.</p>

RESULTS: During a median follow-up of 11.4 years, 3402 (2.21%) cases occurred. After adjustment for all potential confounders, a higher E-DII was associated with an increased risk of incident CKD (HR for 1 unit increment: 1.05 (1.00-1.10), p = 0.034). According to the result of the restricted cubic spline, when E-DII > 1.857, the risk of early-stage CKD would increase significantly.</p>

CONCLUSIONS: A higher pro-inflammatory diet was associated with an increased risk of early-stage CKD in the fully adjusted model. An anti-inflammatory diet may serve as a potential preventive strategy for early-stage CKD, although causal inference cannot be established from this observational study.</p>

Abstract

16 Keywords

10 Authors