| Title: | Gut Microbiome Mediates the Causal Link Between Autism Spectrum Disorder and Dietary Preferences: A Mendelian Randomization Study |
| Journal: | International Journal of Molecular Sciences |
| Published: | 20 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41752141/ |
| DOI: | https://doi.org/10.3390/ijms27042006 |
| URL: | http://dx.doi.org/10.3390/ijms27042006 |
Publication 17690
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Abstract
Autism spectrum disorder (ASD) frequently co-occurs with malnutrition and gut dysbiosis, yet the underlying mechanisms remain poorly understood. Herein, this cross-sectional study first profiles dietary intake differences using dietary records from 210,874 participants (ASD = 232; non-ASD = 210,642; median age = 56.18) from the UK Biobank (UKB). Second, a bi-directional Mendelian Randomization (MR) approach serves to dissect relationships between ASD genetic susceptibility and dietary preferences by leveraging genome-wide association metadata from the iPSYCH-PGC (ASD) and UKB (dietary intake/food-liking traits). The same strategy is implemented to identify ASD-associated gut microbial species. Mediation analyses further assess the role of gut microbiota in the association between ASD and dietary preferences. Subjects with ASD exhibit higher consumption of cheese, processed meat, and oily fish, alongside lower intake of fruits, and demonstrate a preference for high-fat/salt and energy-dense foods. Additionally, the depletion of Turicibacter, Streptococcus, and Lachnospiraceae NK4A136 was causally related with ASD (all false discovery rate < 0.05; β = -0.15, β = -0.10, β = -0.093, respectively), which significantly mediates the ASD-associated elevated preference for high-fat/salt foods. In conclusion, ASD is associated with specific dietary preferences, likely mediated via gut microbiota, highlighting the future potential of gut microbiome-based therapeutics to modify eating disorders for ASD.</p>
13 Keywords
- Adult
- Autism Spectrum Disorder
- Cross-Sectional Studies
- Diet
- Female
- Food Preferences
- Gastrointestinal Microbiome
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Mendelian Randomization Analysis
- Middle Aged
9 Authors
- Yuqi Wu
- Oscar W H Wong
- Sizhe Chen
- Yun Wang
- Guoqing Zhang
- Ying Gao
- Francis K L Chan
- Siew Chien Ng
- Qi Su
1 Application
| Application ID | Title |
|---|---|
| 77803 | Characterization of genetic and phenotypic of obstructive sleep apnea and the potential risk factor of stroke. |
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