| Title: | C-reactive protein predicts respiratory failure in chronic obstructive pulmonary disease: a cohort analysis from the UK Biobank. |
| Journal: | Journal of Global Health |
| Published: | 27 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41757812/ |
| DOI: | https://doi.org/10.7189/jogh.16.04061 |
| URL: | http://dx.doi.org/10.7189/jogh.16.04061 |
Publication 17602
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Abstract
Background: Respiratory failure (RF) is the leading cause of death in chronic obstructive pulmonary disease (COPD), yet reliable biomarkers for early risk stratification remain unclear. Circulating C-reactive protein (CRP) reflects systemic inflammation, but its prognostic value for incident RF in COPD is controversial.</p>
Methods: A total of 38 933 patients from the UK Biobank with the ratio of Forced Expiratory Volume in 1 second to Forced Vital Capacity (FEV1/FVC) < 0.70 but without RF at baseline were included, and a maximum of 17.87 years of follow-up was conducted. Participants were divided into five subgroups based on serum CRP concentration. Kaplan-Meier survival analysis was utilised to assess the correlation between CRP stratification, incident RF, all-cause mortality, and COPD-induced mortality. The dose-response relationship between CRP concentration and incident RF was investigated using Cox proportional hazards regression.</p>
Results: Kaplan-Meier curves showed statistically significant differences in RF across all subgroups throughout the entire follow-up period. Additionally, significant differences were observed between groups concerning all-cause mortality and COPD-induced mortality as well. The Cox proportional hazards model demonstrated a clear dose-response relationship between CRP concentration and RF, even after adjustment for several clinical covariates and systemic inflammation index.</p>
Conclusions: Serum CRP concentration may forecast a high risk of incident RF in patients with COPD, indicating further research on the threshold.</p>
16 Keywords
- Aged
- Biological Specimen Banks
- Biomarkers
- C-Reactive Protein
- Cohort Studies
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Prognosis
- Proportional Hazards Models
- Pulmonary Disease, Chronic Obstructive
- Respiratory Insufficiency
- UK Biobank
- United Kingdom
5 Authors
- Boyan Zhang
- Zhongshang Dai
- Qi Jiang
- Rui Zhao
- Yan Chen
1 Application
| Application ID | Title |
|---|---|
| 105139 | Identifying dietary risk factors of stroke and stroke-related diseases. |
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