| Title: | Healthy lifestyle and Alzheimer's disease in individuals with hyperlipidemia: A prospective cohort study |
| Journal: | The Journal of Prevention of Alzheimer's Disease |
| Published: | 27 Feb 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41763009/ |
| DOI: | https://doi.org/10.1016/j.tjpad.2026.100520 |
| URL: | http://dx.doi.org/10.1016/j.tjpad.2026.100520 |
Publication 17597
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Abstract
BACKGROUND: Whether healthy lifestyle behaviors are associated with Alzheimer's disease (AD) risk among individuals with hyperlipidemia remains unclear.</p>
METHODS: We analyzed 241,642 dementia-free participants from the UK Biobank. A weighted lifestyle score (0-7) was derived from seven factors and categorized into five tiers. Hyperlipidemia was defined as lipid-lowering medication use or LDL-cholesterol ≥ 4.0 mmol/L. Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs).</p>
RESULTS: Over a median follow-up of 14.5 years, 1728 AD cases occurred, including 977 cases among 104,082 individuals with hyperlipidemia. Compared with the intermediate tier, unhealthy lifestyle was associated with elevated AD risk (HR: 1.17; 95% CI: 1.02-1.35), while healtshy and very healthy tiers were associated with progressively lower risk (HR=0.85 and 0.74, respectively). These associations were evident among individuals with hyperlipidemia, but not statistically significant among those without hyperlipidemia.</p>
CONCLUSIONS: Healthy lifestyle patterns were associated with lower AD risk among individuals with hyperlipidemia, with greater risk reductions observed for healthier lifestyle tiers.</p>
6 Authors
- Danyang Sun
- Linling Yu
- Chenqi Liao
- Yuzhong Xu
- Wei Liu
- Xiong Wang
1 Application
| Application ID | Title |
|---|---|
| 106528 | Big Data Mining and Deep Learning to Improve Risk Prediction, Early diagnosis and Prognosis Evaluation of Chronic Diseases |
Enabling scientific discoveries that improve human health