| Title: | Associations of accelerometer-derived moderate-to-vigorous physical activity and atrioventricular block in a healthy elderly population |
| Journal: | Heart Rhythm |
| Published: | 9 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39798681/ |
| DOI: | https://doi.org/10.1016/j.hrthm.2025.01.005 |
Publication 14879
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Abstract
BACKGROUND: There is limited information on protective factors related to atrioventricular (AV) block.</p>
OBJECTIVE: This study examines the association between accelerometer-derived moderate-to-vigorous physical activity (MVPA) and AV block in healthy elderly individuals.</p>
METHODS: A total of 23,590 UK Biobank participants ≥60 years of age involved in a wrist-worn accelerometer study with no history of hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease were analyzed. The associations of MVPA with primary (second- or third-degree AV block) and secondary outcome (third-degree AV block, pacemaker implantation) were evaluated by Cox regression analysis. The associations of MVPA with electrocardiogram parameters were evaluated by linear regression analysis.</p>
RESULTS: The mean age was 63.8 ± 2.8 years, and 57.4% were women. During the median follow-up period of 6.1 years, 115 primary outcome events occurred. Compared with quintile 1 (< 89 min/week), those in quintile 4 (280-449 min/week) had a 63% lower incidence of primary outcome (hazard ratio [HR] 0.37, 95% confidence interval [CI] 0.19-0.73, P = .004); however, the result was attenuated in quintile 5. This pattern was consistently observed in the relationship between MVPA and third-degree AV block (quintile 4 vs quintile 1: HR 0.29, 95% CI 0.11-0.74, P = .010) and pacemaker implantation. MVPA per 150 minutes per week increase was independently negatively associated with normalized PQ interval (msec) (β: -2.13, 95% CI 0-3.03 to -1.24, P < .001).</p>
CONCLUSION: In the healthy elderly population, MVPA was associated with a lower risk of second- or third-degree AV block, which correlates with the reduction of normalized PQ interval. However, excessive MVPA attenuated the results.</p>
13 Keywords
- Accelerometry
- Aged
- Atrioventricular Block
- Electrocardiography
- Exercise
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Risk Factors
- United Kingdom
13 Authors
- Ho-Gi Chung
- Pil-Sung Yang
- Eunsun Jang
- Juntae Kim
- Min Kim
- Daehoon Kim
- Hee Tae Yu
- Tae-Hoon Kim
- Jae-Sun Uhm
- Jung-Hoon Sung
- Hui-Nam Pak
- Moon-Hyoung Lee
- Boyoung Joung
1 Application
| Application ID | Title |
|---|---|
| 77793 | The causal inference study to determine the association of genetically predicted biological, behavioral, ethnic factors with risk of atrial fibrillation and its associated complications. |
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