| Title: | Dietary copper to zinc ratio intake and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank |
| Journal: | American Journal of Epidemiology |
| Published: | 2 Dec 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39657613/ |
| DOI: | https://doi.org/10.1093/aje/kwae412 |
Publication 14068
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Studies have suggested that dietary copper and zinc intake may be associated with irritable bowel syndrome (IBS); however, prospective evidence is lacking. This study aimed to prospectively investigate the relationship between dietary copper, zinc, and copper to zinc (Cu/Zn) ratio intake and the development of IBS in a long-term cohort. A total of 175 421 participants in the UK Biobank without IBS at baseline were included. Dietary intake was assessed by the Oxford WebQ. New-onset IBS was identified using ICD-10 codes (K58). Cox proportional hazard models were applied. During a median follow-up of 13.3 years, 2240 individuals were newly diagnosed with IBS. Copper, zinc, and Cu/Zn ratio intakes all showed U-shaped relationships with IBS incidence. When copper intake was <1.5 mg/day and zinc intake was <10 mg/day, the risk of IBS significantly decreased with increasing copper and zinc intakes (hazard ratio [HR] copper, 0.791, 95% CI, 0.647-0.967; HR zinc, 0.967, 95% CI, 0.937-0.998). No significant association was found when copper intake was ≥1.5 mg/day and zinc intake was ≥10 mg/day. Subgroup analysis suggested a moderate increase in zinc intake was more helpful for preventing IBS in participants younger than 60 years old. Moderately increasing dietary zinc intake and maintaining dietary copper and Cu/Zn ratio within a reasonable range may be beneficial in reducing IBS incidence.</p>
9 Authors
- Yan Zhuang
- Laifu Li
- Yan Ran
- Yanqi Zhang
- Jiamiao Chen
- Xuna Liu
- Beibei Zeng
- Boxu Zhu
- Fei Dai
Enabling scientific discoveries that improve human health