| Title: | Cannabis Use Is Associated With Lower COVID-19 Susceptibility but Poorer Survival |
| Journal: | Frontiers in Public Health |
| Published: | 1 Apr 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35433589/ |
| DOI: | https://doi.org/10.3389/fpubh.2022.829715 |
Publication 13897
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Abstract
Objectives: To investigate the impact of cannabis use on the infection and survival outcomes of COVID-19.</p>
Study Design: Cross-sectional study based on the UK Biobank (UKB) dataset.</p>
Methods: We identified 13,099 individuals with cannabis smoking history in the UKB COVID-19 Serology Study. The Charlson-Quan Comorbidity Index was estimated using inpatient ICD-10 records. Multivariable logistic regression characterized features associated with COVID-19 infection. Cox models determined the hazard ratios (HR) for COVID-19-related survival.</p>
Results: Cannabis users were more likely to getting COVID-19 (odds ratio: 1.22, P = 0.001) but multivariable analysis showed that cannabis use was a protective factor of COVID-19 infection (adjusted odds ratio: 0.81, P = 0.001). Regular cannabis users, who smoked more than once per month, had a significantly poorer COVID-19-related survival, after adjusting for known risk factors including age, gender, smoking history, and comorbidity (adjusted hazard ratio: 2.81, P = 0.041).</p>
Conclusions: The frequency of cannabis use could be considered as a candidate predictor for mortality risk of COVID-19.</p>
6 Keywords
- COVID-19
- Cannabis
- Comorbidity
- Cross-Sectional Studies
- Humans
- Marijuana Smoking
3 Authors
- Da Huang
- Roubing Xu
- Rong Na
1 Application
| Application ID | Title |
|---|---|
| 66813 | Comprehensive evaluation of causal relationship among different phenotypes and disease traits by Mendelian Randomization using Genetic Instruments |
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