| Title: | The Association Between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank |
| Journal: | Nutrients |
| Published: | 28 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39519494/ |
| DOI: | https://doi.org/10.3390/nu16213661 |
| URL: | https://www.mdpi.com/2072-6643/16/21/3661/pdf |
Publication 13192
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Abstract
Objective: Approximately 30% of adults globally suffer from sleep disorders. However, there are few longitudinal studies on the association between dietary vitamin C and sleep disorders. This study aimed to investigate the association between dietary vitamin C intake and various types of sleep disorders, including sleep apnea and insomnia. Methods: We enrolled 68,221 participants from the UK Biobank. Dietary vitamin C intake was assessed using a 24 h dietary recall questionnaire. We employed a Cox regression model to assess the association between dietary vitamin C and sleep disorders and used restricted cubic spline models to investigate potential nonlinear relationships. Stratified and sensitivity analyses were also conducted to validate the findings. Results: The results indicated that vitamin C intake at the Q4 level (132.88-191.51 mg/d) was significantly associated with a reduced risk of sleep disorders, with an HR (95% CI) of 0.78 (0.65-0.94), and against sleep apnea, with an HR (95% CI) of 0.75 (0.62-0.92). The protective effect persisted significant in stratified analyses of men and those aged ≤ 60 years; the results were consistent in the sensitivity analyses. Conclusions: Our findings suggest that sufficient dietary vitamin C intake may help to prevent sleep disorders.</p>
17 Keywords
- Adult
- Aged
- Ascorbic Acid
- Biological Specimen Banks
- Cohort Studies
- Diet
- Female
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Sleep Apnea Syndromes
- Sleep Initiation and Maintenance Disorders
- Sleep Wake Disorders
- Surveys and Questionnaires
- UK Biobank
- United Kingdom
5 Authors
- Qiuge Zhang
- Xueting Qi
- Zhaoguo Wang
- Dongfeng Zhang
- Tong Wang
1 Application
| Application ID | Title |
|---|---|
| 95715 | Effects of genomic, metabolomic, environmental and clinical factors on neurological and psychiatric disorders, and construction of predictive models |
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