| Title: | The association between plasma fatty acids and risk of lung cancer: a prospective cohort study of the UK Biobank |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 3 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39225141/ |
| DOI: | https://doi.org/10.1210/clinem/dgae609 |
Publication 13032
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Abstract
CONTEXT: Fatty acids (FAs) have emerged as significant contributors to tumorigenesis, yet prospective evidence regarding their specific effects on lung cancer risk remains scarce.</p>
OBJECTIVE: To investigate the association between plasma FAs and lung cancer incidence, as well as a potential modification effect of genetic susceptibility on lung cancer risk.</p>
METHODS: A cohort study was conducted involving 112,547 cancer-free participants from the UK Biobank, with measurements of plasma FAs, including saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) at baseline (2006-2010). Cox regression models were employed to assess lung cancer risk according to plasma FA quartiles or 1-SD increment. Furthermore, interaction between plasma FAs and polygenic risk score (PRS) was evaluated using an additive model.</p>
RESULTS: Over an average 10.9-year follow-up, 1122 lung cancer cases occurred. After multivariable adjustment, MUFAs were positively associated with lung cancer risk (hazard ratio [HR] per 1-SD = 1.32, 95% confidence interval [CI]: 1.13-1.54). In contrast, PUFAs, particularly n-3 PUFAs, n-6 PUFAs, docosahexaenoic acid, and linoleic acid, were associated with a lower risk of lung cancer, with HRs ranging from 0.79 (95% CI: 0.72-0.87) to 0.89 (95% CI: 0.83-0.95). SFAs were not significantly associated with lung cancer risk. Moreover, we observed an additive interaction between plasma PUFAs and genetic risk. Individuals with a high genetic risk and the lowest quartile of plasma PUFAs had the highest risk of lung cancer (HR = 2.20, 95% CI: 1.43-3.38).</p>
CONCLUSION: Our findings suggest that plasma PUFAs may serve as protective factors, while MUFAs represent risk factors for lung cancer, offering novel insights into lung cancer carcinogenesis and prevention.</p>
10 Authors
- Jianv Huang
- Jiacong Li
- Lu He
- Junyan Miao
- Meng Zhu
- Juncheng Dai
- Guangfu Jin
- Hongxia Ma
- Dong Hang
- Hongbing Shen
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