| Title: | EAT-Lancet Diet Pattern, Genetic Predisposition, Inflammatory Biomarkers, and Risk of Lung Cancer Incidence and Mortality |
| Journal: | Molecular Nutrition & Food Research |
| Published: | 5 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39233532/ |
| DOI: | https://doi.org/10.1002/mnfr.202400448 |
Publication 13022
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Abstract
SCOPE: The association between a planetary and sustainable EAT-Lancet diet and lung cancer remains inconclusive, with limited exploration of the role of genetic susceptibility and inflammation.</p>
METHODS AND RESULTS: The study includes 175 214 cancer-free participants in the UK Biobank. Fourteen food components are collected from a 24-h dietary recall questionnaire. A polygenic risk score is constructed through capturing the overall risk variants for lung cancer. Sixteen inflammatory biomarkers are assayed in blood samples. Participants with the highest EAT-Lancet diet scores (≥12) have a lower risk of lung cancer incidence (hazard ratio [HR] = 0.64, 95% confidence interval [CI]: 0.51-0.80) and mortality (HR = 0.65, 95% CI: 0.48-0.88), compared to those with the lowest EAT-Lancet diet scores (≤8). Interestingly, there is a significantly protective trend against both lung adenocarcinoma and lung squamous cell carcinoma with higher EAT-Lancet diet scores. Despite no significant interactions, a risk reduction trend for lung cancer is observed with increasing EAT-Lancet diet scores and decreasing genetic risk. Ten inflammatory biomarkers partially mediate the association between the EAT-Lancet diet and lung cancer risk.</p>
CONCLUSION: The study depicts a lower risk of lung cancer conferred by the EAT-Lancet diet associated with lower inflammation levels among individuals with diverse genetic predispositions.</p>
13 Authors
- Fubin Liu
- Changyu Si
- Linlin Chen
- Yu Peng
- Peng Wang
- Xixuan Wang
- Jianxiao Gong
- Huijun Zhou
- Jiale Gu
- Ailing Qin
- Ming Zhang
- Liangkai Chen
- Fangfang Song
1 Application
| Application ID | Title |
|---|---|
| 86898 | Non-genetic risk exposures, genetic predisposition, and complex diseases |
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