| Title: | A bimodal taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients |
| Journal: | Neuron |
| Published: | 22 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39178859/ |
| DOI: | https://doi.org/10.1016/j.neuron.2024.07.023 |
| URL: | https://kclpure.kcl.ac.uk/portal/en/publications/d5e316c0-2215-40fd-aaea-a94dd56f39c6 |
Publication 13006
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Abstract
We developed a computational pipeline (now provided as a resource) for measuring morphological similarity between cortical surface sulci to construct a sulcal phenotype network (SPN) from each magnetic resonance imaging (MRI) scan in an adult cohort (n = 34,725; 45-82 years). Networks estimated from pairwise similarities of 40 sulci on 5 morphological metrics comprised two clusters of sulci, represented also by the bimodal distribution of sulci on a linear-to-complex dimension. Linear sulci were more heritable and typically located in unimodal cortex, and complex sulci were less heritable and typically located in heteromodal cortex. Aligning these results with an independent fetal brain MRI cohort (n = 228; 21-36 gestational weeks), we found that linear sulci formed earlier, and the earliest and latest-forming sulci had the least between-adult variation. Using high-resolution maps of cortical gene expression, we found that linear sulcation is mechanistically underpinned by trans-sulcal gene expression gradients enriched for developmental processes.</p>
12 Keywords
- Aged
- Aged, 80 and over
- Brain
- Cerebral Cortex
- Cohort Studies
- Female
- Fetus
- Gene Expression Regulation, Developmental
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
14 Authors
- William E Snyder
- Petra E Vértes
- Vanessa Kyriakopoulou
- Konrad Wagstyl
- Logan Z J Williams
- Dustin Moraczewski
- Adam G Thomas
- Vyacheslav R Karolis
- Jakob Seidlitz
- Denis Rivière
- Emma C Robinson
- Jean-Francois Mangin
- Armin Raznahan
- Edward T Bullmore
1 Application
| Application ID | Title |
|---|---|
| 22875 | Confirmation and expansion of NIH intramural results related to brain imaging, gene-dose effects and genetic scores |
Enabling scientific discoveries that improve human health