| Title: | Joint effects of sleep disturbance and renal function impairment on incident new-onset severe metabolic dysfunction-associated steatotic liver disease |
| Journal: | Diabetes Obesity and Metabolism |
| Published: | 8 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39118216/ |
| DOI: | https://doi.org/10.1111/dom.15841 |
Publication 12971
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Abstract
AIM: To elucidate the effects of sleep parameters and renal function on the risk of developing new-onset severe metabolic dysfunction-associated steatotic liver disease (MASLD).</p>
MATERIALS AND METHODS: The primary analysis involved a cohort of 305 257 participants. Multivariable Cox models were employed to calculate hazard ratios and 95% confidence intervals. Traditional mediation and two-step Mendelian randomization (MR) analyses were conducted to assess the associations and mediating roles of renal function indicators between sleep and new-onset severe MASLD.</p>
RESULTS: Poor sleep score and renal function biomarker score (RFS) were associated with an increased risk of new-onset severe MASLD (all ptrend <0.001). Participants with poor sleep patterns and the highest RFS had a 5.45-fold higher risk of new-onset severe MASLD, compared to those with healthy sleep patterns and the lowest RFS (p < 0.001). The RFS could explain 10.08% of the correlations between poor sleep score and risk of new-onset severe MASLD. Additionally, MR analyses supported a causal link between insomnia and new-onset severe MASLD and revealed a mediating role of chronic kidney disease in the connection between insomnia and new-onset severe MASLD risk.</p>
CONCLUSIONS: This study highlights the independent and combined associations of sleep parameters and renal function indicators with new-onset severe MASLD, underscoring the bidirectional communication of the liver-kidney axis and providing modifiable strategies for preventing MASLD.</p>
9 Authors
- Tian Tian
- Jing Zeng
- Yuan-Cheng Li
- Jing Wang
- Dan-Feng Zhang
- De-Guang Wang
- Hai-Feng Pan
- Jian-Gao Fan
- Jing Ni
1 Application
| Application ID | Title |
|---|---|
| 80827 | Dissecting the relationships between autoimmune rheumatic diseases and cancer |
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