| Title: | The association between periodontal disease and cardiovascular disease: insights from imaging, observational and genetic data |
| Journal: | JACC Advances |
| Published: | 1 Aug 2024 |
| DOI: | https://doi.org/10.1016/j.jacadv.2024.101241 |
Publication 12940
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Abstract
Background Periodontal disease is the sixth most common disease worldwide and may be a contributory risk factor for cardiovascular disease (CVD). Objectives This study utilizes non-invasive cardiac imaging, longitudinal and genetic data to characterize the association between periodontal disease and both cardiovascular magnetic resonance (CMR) imaging biomarkers of remodeling and incident coronary artery disease (CAD). Methods 481,915 individuals from the UK Biobank were included, 91,022 (18.9%) of whom had self-reported periodontal disease. For imaging analysis, 59,019 had paired CMR data. Multivariable linear regression models were constructed to examine the association of periodontal disease on CMR outcomes. The endpoints for the CMR analyses were LV end-diastolic volume, LV ejection fraction, LV mass, LV mass:volume ratio, LV global longitudinal strain and native T1 values. The relationship between periodontal disease and CVD was assessed using Cox proportional hazards regression models, with incident CAD as the endpoint. To examine the relationship of genetically-determined periodontal disease on CAD, a genome-wide polygenic risk score was constructed. Results Periodontal disease was associated with a significantly higher LV mass:volume ratio (effect size = 0.00233, 95% CI = 0.0006, 0.004) and significantly lower T1 values (effect size = -0.86 ms, 95% CI = -1.63, -0.09). Periodontal disease was independently associated with an increased hazard of incident CAD (HR = 1.09, 95% CI = 1.07, 1.13) at a median follow-up time of 13.8 years. Each standard deviation increase in the periodontal disease PRS was associated with increased odds of CAD (OR = 1.03, 95% CI = 1.02, 1.05). Conclusions Using an integrated approach across imaging, observational and genomic data, periodontal disease is associated with biomarkers of subclinical remodeling as well as incident CAD. These findings highlight the potential importance of periodontal disease in the broader context of CVD prevention.</p>
7 Authors
- Mihir M. Sanghvi
- Julia Ramírez
- Sucharitha Chadalavada
- Nay Aung
- Patricia B. Munroe
- Nikolaos Donos
- Steffen E. Petersen
1 Application
| Application ID | Title |
|---|---|
| 2964 | Description of cardiovascular phenotype in the UK Biobank population based on cardiovascular magnetic resonance and carotid ultrasound |
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