| Title: | Influence of intraocular and blood pressure on brain volumes: observational and Mendelian Randomization analyses |
| Journal: | iScience |
| Published: | 1 Aug 2024 |
| DOI: | https://doi.org/10.1016/j.isci.2024.110817 |
Publication 12932
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Abstract
Intraocular pressure (IOP) is closely correlated with blood pressure (BP), and while BP has been linked to brain volumes, the effect of IOP on brain volumes remains unclear. This study analyzed participants from the UK Biobank with MRI-measured brain volumes. Observational analyses included 8,634 participants for IOP and 36,069 for BP, followed by Mendelian Randomisation (MR) analyses of 37,410 participants. Observational analyses revealed that each 10-mmHg increase in diastolic BP was linked to a 0.13 ml larger white matter hyperintensity (WMH) after adjusting for covariates. Associations between IOP and brain volumes were more pronounced in younger individuals or those without hypertension. MR analyses confirmed significant relationships between diastolic BP and WMH, and each 5-mmHg increase in IOP reduced grey matter volumes by 3.24 ml. The study suggests that targeting IOP and BP could help prevent brain volume reduction.</p>
15 Authors
- Xianwen Shang
- Yu Huang
- Susan Zhu
- Zhuoting Zhu
- Xueli Zhang
- Wei Wang
- Xiayin Zhang
- Jing Liu
- Jiahao Liu
- Shulin Tang
- Zongyuan Ge
- Yijun Hu
- Honghua Yu
- Xiaohong Yang
- Mingguang He
1 Application
| Application ID | Title |
|---|---|
| 86091 | Regulators of the association between ocular disorders and systemic diseases. |
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