| Title: | Dietary Fiber, Genetic Variations of Gut Microbiota-derived Short-chain Fatty Acids, and Bone Health in UK Biobank |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 14 Oct 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33051670/ |
| DOI: | https://doi.org/10.1210/clinem/dgaa740 |
| URL: | https://academic.oup.com/jcem/article-pdf/106/1/201/41848111/dgaa740.pdf |
| Citations: | 23 (13 in last 2 years) as of 8 Aug 2024 |
Publication 12898
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
CONTEXT: Dietary fiber intake may relate to bone health.</p>
OBJECTIVE: To investigate whether dietary fiber intake is associated with bone mineral density (BMD), and the modification effect of genetic variations related to gut microbiota-derived short-chain fatty acids (SCFAs).</p>
DESIGN: The associations of dietary fiber intake with estimated BMD derived from heel ultrasound and fractures were assessed in 224 630 and 384 134 participants from the UK Biobank.</p>
SETTING: UK Biobank.</p>
MAIN OUTCOME MEASURES: Estimated BMD derived from heel ultrasound.</p>
RESULTS: Higher dietary fiber intake (per standard deviation) was significantly associated with higher heel-BMD (β [standard error] = 0.0047 [0.0003], P = 1.10 × 10-54). Similarly significant associations were observed for all the fiber subtypes including cereal, fruit (dried and raw), and vegetable (cooked and raw) (all P < .05). A positive association was found in both women and men but more marked among men except for dietary fiber in cooked vegetables (all Pinteraction < .05). A protective association was found between dietary fiber intake and hip fracture (hazard ratio, 95% confidence interval: 0.94, 0.89-0.99; P = 3.0 × 10-2). In addition, the association between dietary fiber and heel BMD was modified by genetically determined SCFA propionate production (Pinteraction = 5.1 × 10-3). The protective association between dietary fiber and heel BMD was more pronounced among participants with lower genetically determined propionate production.</p>
CONCLUSIONS: Our results indicate that greater intakes of total dietary fiber and subtypes from various food sources are associated with higher heel-BMD. Participants with lower genetically determined propionate production may benefit more from taking more dietary fiber.</p>
19 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Bone Density
- Bone and Bones
- Calcaneus
- Cohort Studies
- Dietary Fiber
- Eating
- Fatty Acids, Volatile
- Female
- Fractures, Bone
- Gastrointestinal Microbiome
- Genetic Variation
- Humans
- Male
- Middle Aged
- Ultrasonography
- United Kingdom
6 Authors
- Tao Zhou
- Mengying Wang
- Hao Ma
- Xiang Li
- Yoriko Heianza
- Lu Qi
1 Application
| Application ID | Title |
|---|---|
| 29256 | Study of gene-environment interaction and Mendelian randomization of obesity and cardiometabolic risk |
Enabling scientific discoveries that improve human health