| Title: | Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health |
| Journal: | European Respiratory Journal |
| Published: | 26 Nov 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33243845/ |
| DOI: | https://doi.org/10.1183/13993003.03091-2020 |
| URL: | https://erj.ersjournals.com/content/erj/57/5/2003091.full.pdf |
| Citations: | 113 (69 in last 2 years) as of 8 Aug 2024 |
Publication 12895
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Abstract
There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients identified using nationwide health registries.We estimated 0.08 (95% CI 0.06-0.11) heritability and identified five loci associated with OSA (p<5.0×10-8): rs4837016 near GAPVD1 (GTPase activating protein and VPS9 domains 1), rs10928560 near CXCR4 (C-X-C motif chemokine receptor type 4), rs185932673 near CAMK1D (calcium/calmodulin-dependent protein kinase ID) and rs9937053 near FTO (fat mass and obesity-associated protein; a variant previously associated with body mass index (BMI)). In a BMI-adjusted analysis, an association was observed for rs10507084 near RMST/NEDD1 (rhabdomyosarcoma 2 associated transcript/NEDD1 γ-tubulin ring complex targeting factor). We found high genetic correlations between OSA and BMI (rg=0.72 (95% CI 0.62-0.83)), and with comorbidities including hypertension, type 2 diabetes, coronary heart disease, stroke, depression, hypothyroidism, asthma and inflammatory rheumatic disease (rg>0.30). The polygenic risk score for BMI showed 1.98-fold increased OSA risk between the highest and the lowest quintile, and Mendelian randomisation supported a causal relationship between BMI and OSA.Our findings support the causal link between obesity and OSA, and the joint genetic basis between OSA and comorbidities.</p>
8 Keywords
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
- Body Mass Index
- Diabetes Mellitus, Type 2
- Genome-Wide Association Study
- Humans
- Hypertension
- Risk Factors
- Sleep Apnea, Obstructive
23 Authors
- Satu Strausz
- Sanni Ruotsalainen
- Hanna M. Ollila
- Juha Karjalainen
- Tuomo Kiiskinen
- Mary Reeve
- Mitja Kurki
- Nina Mars
- Aki S. Havulinna
- Elina Luonsi
- Dina Mansour Aly
- Emma Ahlqvist
- Maris Teder-Laving
- Priit Palta
- Leif Groop
- Reedik Mägi
- Antti Mäkitie
- Veikko Salomaa
- Adel Bachour
- Tiinamaija Tuomi
- Aarno Palotie
- Tuula Palotie
- Samuli Ripatti
1 Application
| Application ID | Title |
|---|---|
| 22627 | Fine-mapping genotype-phenotype associations |
Enabling scientific discoveries that improve human health