| Title: | Analysis of the Association Between Pathogen Exposure and the Risk of Dementia. |
| Journal: | Journal of Alzheimer's Disease |
| Published: | 1 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38995782/ |
| DOI: | https://doi.org/10.3233/jad-240073 |
Publication 12866
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Abstract
Background: Previous research has suggested that pathogen infections may serve as potential contributors to dementia.</p>
Objective: Consequently, the study aimed to evaluate whether pathogen exposure heightens the risk of dementia.</p>
Methods: Between 2006 and 2010, a total of 8,144 individuals from the UK Biobank had data on pathogen antibodies and were included in the baseline assessment. Cox proportional hazard models were employed for the analysis.</p>
Results: Out of the 8,144 participants, 107 eventually developed dementia, while 55 participants were diagnosed with Alzheimer's disease (AD). Multivariate Cox regression analysis revealed that the levels of pathogen antibody titers of EBV and C. trachomatis were associated with an increased risk of dementia/AD. The highest quartile of EBV EBNA-1 and EBV VCA p18, and the second quartile of H. pylori VacA significantly increased the risk of dementia compared lower quartile (EBV EBNA-1: HR = 1.938, p = 0.018; EBV VCA p18: HR = 1.824, p = 0.040; H. pylori VacA: HR = 1.890, p = 0.033). Besides, the highest quartile of EBV VCA p18 had a higher risk of AD compared lower quartile (HR = 2.755, p = 0.029).</p>
Conclusions: The study demonstrated that exposure to EBV, H. pylori, and C. trachomatis substantially elevated the risk of dementia/AD. Despite the relatively widespread occurrence of EBV infection in the population, elevated pathogen antibody titers were still found to increase the risk of dementia/AD. Besides, since C. trachomatis and C. pneumoniae are quite homologous, this study found that trachomatis (C. trachomatis/C. pneumoniae) may be significantly associated with the risk of AD/dementia.</p>
17 Keywords
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Antibodies, Bacterial
- Antibodies, Viral
- Dementia
- Epstein-Barr Virus Infections
- Female
- Helicobacter Infections
- Helicobacter pylori
- Herpesvirus 4, Human
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Risk Factors
- United Kingdom
5 Authors
- Jiajia Fu
- Qianqian Wei
- Xueping Chen
- Xiaohui Lai
- Huifang Shang
1 Application
| Application ID | Title |
|---|---|
| 98992 | Precision medicine of central nervous system diseases combining demographics, imaging, genetics, and other omics |
Enabling scientific discoveries that improve human health