| Title: | Quantitative Imaging Reveals Steatosis and Fibroinflammation in Multiple Organs in People With Type 2 Diabetes: A Real-World Study |
| Journal: | Diabetes |
| Published: | 14 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38748492/ |
| DOI: | https://doi.org/10.2337/db23-0926 |
| URL: | https://diabetesjournals.org/diabetes/article-pdf/doi/10.2337/db23-0926/765322/db230926.pdf |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 12864
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
We aimed to determine the extent of multiorgan fat accumulation and fibroinflammation in individuals living with type 2 diabetes. We deeply phenotyped individuals with type 2 diabetes (134 from secondary care, 69 from primary care) with multiorgan, quantitative, multiparametric MRI and compared with 134 matched control individuals without diabetes and 92 control individuals with normal weight. We examined the impact of diabetes duration, obesity status, and glycemic control. Ninety-three of the individuals with type 2 diabetes were reevaluated at 7 months (median). Multiorgan abnormalities were more common in individuals with type 2 diabetes (94%) than in age- and BMI-matched healthy individuals or healthy individuals with normal weight. We demonstrated a high burden of combined steatosis and fibroinflammation within the liver, pancreas, and kidneys (41%, 17%, and 10%) associated with visceral adiposity (73%) and poor vascular health (82%). Obesity was most closely associated with advanced liver disease, renal and visceral steatosis, and multiorgan abnormalities, while poor glycemic control was associated with pancreatic fibroinflammation. Pharmacological therapies with proven cardiorenal protection improved liver and vascular health unlike conventional glucose-lowering treatments, while weight loss or improved glycemic control reduced multiorgan adiposity (P ≤ 0.01). Quantitative imaging in people with type 2 diabetes highlights widespread organ abnormalities and may provide useful risk and treatment stratification.</p>
ARTICLE HIGHLIGHTS: </p>
15 Keywords
- Adult
- Aged
- Diabetes Mellitus, Type 2
- Fatty Liver
- Female
- Fibrosis
- Humans
- Inflammation
- Kidney
- Liver
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Obesity
- Pancreas
10 Authors
- Charlie Diamond
- Michele Pansini
- Azlinda Hamid
- Nicole Eichert
- Prashant Pandya
- Sarah N. Ali
- Graham J. Kemp
- Gaya Thanabalasingham
- Helena Thomaides Brears
- Daniel J. Cuthbertson
1 Application
| Application ID | Title |
|---|---|
| 9914 | Determining the Outcomes of People with Liver Disease |
Enabling scientific discoveries that improve human health