| Title: | Association of peripheral inflammatory indicators with osteoarthritis risk |
| Journal: | Osteoarthritis and Cartilage Open |
| Published: | 19 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39021876/ |
| DOI: | https://doi.org/10.1016/j.ocarto.2024.100496 |
| URL: | http://dx.doi.org/10.1016/j.ocarto.2024.100496 |
Publication 12861
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Abstract
Objectives: Numerous studies have established the role of inflammation in osteoarthritis (OA) progression, yet limited research explores the association between systemic inflammatory indicators and pre-diagnosis OA risk. This study aimed to investigate the association between peripheral inflammatory indicators and the risk of OA using data from the UK Biobank.</p>
Methods: The study analyzed data from 417,507 participants in the UK Biobank, including neutrophil count, lymphocyte count, monocyte count, platelet count, and C-reactive protein meter. Additionally, derived ratios such as NLR(neutrophils-lymphocytes ratio), PLR(Platelets-lymphocytes ratio), SII(systemic immune-inflammation index), and LMR (lymphocytes-monocytes ratio) were examined. Cox proportional hazards models and restricted cubic spline models were used to assess both linear and nonlinear associations.</p>
Results: Over a mean follow-up period of 12.7 years, a total of 49,509 OA events were identified. The findings revealed that CRP (HR:1.06, 95%CI:1.05-1.07), NLR (HR:1.02, 95%CI:1.01-1.03), PLR (HR:1.02, 95%CI:1.01-1.03), and SII (HR:1.03, 95%CI:1.01-1.04) were associated with an increased risk of OA, while LMR (HR:0.97, 95%CI:0.96-0.99) showed a significant negative correlation with OA risk. Subgroup analyses further emphasized that these associations were significant across most of the population. Although neutrophils, lymphocytes, monocytes, and platelets showed a nominal association with the risk of OA, the results were unreliable, especially for specific joint OA.</p>
Conclusion: The study provides evidence of a significant association between elevated peripheral inflammatory indicators and OA risk. These findings underscore the importance of low-grade chronic inflammation in OA development. The potential clinical utility of these indicators as early predictors of OA is suggested, warranting further exploration.</p>
11 Authors
- Shiyong Zhang
- Yanlin Zhong
- Xudong Wang
- Wei Jiang
- Xicong Chen
- Yunze Kang
- Zhiwen Li
- Weiming Liao
- Linli Zheng
- Puyi Sheng
- Ziji Zhang
1 Application
| Application ID | Title |
|---|---|
| 71986 | The potential therapeutic effects of metformin in osteoarthritis |
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