| Title: | Serum albumin, genetic susceptibility, and risk of venous thromboembolism |
| Journal: | Research and Practice in Thrombosis and Haemostasis |
| Published: | 1 Jul 2024 |
| DOI: | https://doi.org/10.1016/j.rpth.2024.102509 |
Publication 12860
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Abstract
Background Previous research on the association between serum albumin (ALB) and venous thromboembolism (VTE) has produced inconclusive results. The polygenic risk score is constructed from a set of independent risk variants associated with a disorder, enabling the identification of a larger fraction of the population at comparable or greater disease risk. It is still unknown whether albumin and genetic factors jointly contributed to the incidence of VTE. Objective The present study was to explore the ALB, genetic susceptibility and the risk of VTE. Methods The present investigation was an analysis of prospectively collected data from UK Biobank, a population-based, longitudinal cohort. Cox proportional models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for VTE. The Kaplan-Meier curve was utilized to visualize the cumulative risk of VTE according to different serum albumin levels, and the restricted cubic spline (RCS) model was leveraged to explore the exposure-response relationship among ALB levels and VTE risk. Results During median follow-up of 13.5 years, 11,502 cases with VTE were diagnosed among 417,113 participants in the UK Biobank. The lower ALB levels were associated with a higher risk for VTE. Individuals with both a high genetic risk and lowest ALB level had the highest risk of VTE (HR: 3.89, 95%CI: 3.41-4.43), compared with low genetic risk and highest ALB level. The positive joint effects of low ALB and PRS increased the risk of VTE in high-genetic-risk individuals. This study excluded non-European patients and primarily focused on the European population, which may limit the generalizability of the findings. Conclusion Low serum ALB levels were linked to an increased risk of VTE, which was in accordance with a linear dose-response relationship. There was a positive additive effect of ALB and genetic susceptibility on the risk of VTE. ALB could serve as a biomarker for predicting the risk of VTE.</p>
9 Authors
- Yuyang Sun
- Jun Deng
- Yajie Ding
- Shanshan Luo
- Si Li
- Yunlong Guan
- Xi Cao
- Xingjie Hao
- Yu Hu
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
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