| Title: | Inverse association between lung function and nonalcoholic fatty liver disease: An observational and mendelian randomization study |
| Journal: | Nutrition Metabolism and Cardiovascular Diseases |
| Published: | 15 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39168802/ |
| DOI: | https://doi.org/10.1016/j.numecd.2024.07.007 |
Publication 12856
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND AND AIM: The association between lung function with non-alcoholic fatty liver disease (NAFLD) in the general population remains unknown. We aimed to examine the association between lung function and NAFLD among the general population in an observational and Mendelian randomization (MR) study.</p>
METHODS AND RESULTS: 340, 253 participants without prior liver diseases were included from the UK Biobank. Of these, 30,397 participants had liver proton density fat fraction (PDFF) measurements by magnetic resonance image (MRI). Lung function parameters included forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). The primary outcome was the presence of NAFLD, defined as a PDFF greater than 5.5%. The secondary outcome included incident severe NAFLD and severe liver diseases (including liver cirrhosis, liver failure, hepatocellular carcinoma and liver-related death), defined by the International Classification of Disease codes with different data sources. During a media follow-up duration of 9.3 years, 7335 (24.1%) the presence of NAFLD cases were documented. There was an inverse association of FEV1 (% predicted) (Per SD increment, adjusted OR = 0.91, 95%CI: 0.88-0.94) and FVC (% predicted) (Per SD increment, adjusted OR = 0.90, 95%CI: 0.87-0.92) with the presence of NAFLD. Similar results were found for incident severe NAFLD, severe liver disease, liver cirrhosis, liver failure and liver-related death. MR analyses showed that the genetically predicted FEV1 (adjusted OR = 0.63, 95%CI: 0.46-0.87) and FVC (adjusted OR = 0.69, 95%CI: 0.51-0.95) were both inversely associated with the presence of NAFLD.</p>
CONCLUSIONS: There was an inverse causal relationship between lung function and NAFLD in the general population.</p>
20 Keywords
- Adult
- Aged
- Female
- Forced Expiratory Volume
- Genetic Predisposition to Disease
- Humans
- Incidence
- Lung
- Magnetic Resonance Imaging
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Phenotype
- Risk Assessment
- Risk Factors
- Severity of Illness Index
- Time Factors
- United Kingdom
- Vital Capacity
11 Authors
- Chun Zhou
- Yanjun Zhang
- Ziliang Ye
- Yuanyuan Zhang
- Panpan He
- Mengyi Liu
- Sisi Yang
- Xiaoqin Gan
- Hao Xiang
- Yu Huang
- Xianhui Qin
1 Application
| Application ID | Title |
|---|---|
| 73201 | Identification of residual risks of non-infectious chronic diseases |
Enabling scientific discoveries that improve human health