| Title: | Prospective analysis of circulating biomarkers and ovarian cancer risk in the UK Biobank. |
| Journal: | Cancer Epidemiology Biomarkers & Prevention |
| Published: | 15 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39007864/ |
| DOI: | https://doi.org/10.1158/1055-9965.epi-24-0319 |
Publication 12826
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Abstract
BACKGROUND: Risk factors have limited ability to predict individuals at high risk of developing ovarian cancer among average risk women, highlighting the need for discovery of novel biomarkers. In the UK Biobank, we investigated serum biomarkers commonly measured in clinical laboratory tests and ovarian cancer risk.</p>
METHODS: We conducted a prospective analysis of 20 serum biomarkers and ovarian cancer risk in 232,037 female UK Biobank participants (including 1,122 incident ovarian cancer cases diagnosed from 2006-2020). Multivariable adjusted Cox proportional hazards models were used to examine associations between biomarkers and ovarian cancer risk overall and by histotype. False discovery rate was used to account for multiple testing.</p>
RESULTS: Overall, higher levels of IGF-1 (RRquartile 4 vs. 1=0.73, 95%CI=0.60-0.87; p-trend=0.002/FDR=0.04), HbA1c (RRquartile 4 vs. 1=0.74, 95%CI=0.62-0.89; p-trend=0.002/FDR=0.04), and alanine aminotransferase (RRquartile 4 vs. 1=0.76, 95%CI=0.63-0.91; p-trend=0.002/FDR=0.04) were significantly associated with lower ovarian cancer risk. When stratified by histotype, higher IGF-1 levels were associated with lower risk of serous (RRquartile 4 vs. 1=0.73, 95%CI=0.58-0.91; p-trend=0.01/FDR=0.20) and clear cell tumors (RRquartile 4 vs. 1=0.18, 95%CI=0.07-0.49; p-trend=0.001/FDR=0.02) and higher HbA1c levels were associated with lower risk of serous tumors (RRquartile 4 vs. 1=0.73, 95%CI=0.59-0.90; p-trend=0.004/FDR=0.08).</p>
CONCLUSION: We observed that higher levels of circulating IGF-1, HbA1c, and alanine aminotransferase were associated with lower ovarian cancer risk.</p>
IMPACT: These results suggest metabolism of glucose/amino acid and insulin/IGF-1 signaling pathway may be contributing to ovarian carcinogenesis. Further research is needed to replicate our findings and elucidate how systemic changes in metabolism impact ovarian carcinogenesis.</p>
6 Authors
- Naoko Sasamoto
- Cassandra A Hathaway
- Mary K Townsend
- Kathryn L Terry
- Britton Trabert
- Shelley S Tworoger
1 Application
| Application ID | Title |
|---|---|
| 26189 | Evaluating Biomarkers in Predicting Ovarian Cancer Risk |
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