| Title: | Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank. |
| Journal: | Diabetes Care |
| Published: | 17 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39017683/ |
| DOI: | https://doi.org/10.2337/dc24-0213 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 12814
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Abstract
OBJECTIVE: To evaluate the association between irregular sleep duration and incident diabetes in a U.K. population over 7 years of follow-up.</p>
RESEARCH DESIGN AND METHODS: Among 84,421 UK Biobank participants (mean age: 62 years) who were free of diabetes at the time of providing accelerometer data in 2013-2015 and prospectively followed until May 2022, sleep duration variability was quantified by the within-person SD of 7-night accelerometer-measured sleep duration. We used Cox proportional hazard models to estimate hazard ratios (HRs) for incident diabetes (identified from medical records, death register, and/or self-reported diagnosis) according to categories of sleep duration SD.</p>
RESULTS: There were 2,058 incident diabetes cases over 622,080 person-years of follow-up. Compared with sleep duration SD ≤ 30 min, the HR (95% CI) was 1.15 (0.99, 1.33) for 31-45 min, 1.28 (1.10, 1.48) for 46-60 min, 1.54 (1.32, 1.80) for 61-90 min, and 1.59 (1.33, 1.90) for ≥91 min, after adjusting for age, sex, and race. We found a nonlinear relationship (p nonlinearity 0.0002), with individuals with a sleep duration SD of >60 vs. ≤60 min having 34% higher diabetes risk (95% CI 1.22, 1.47). Further adjustment for lifestyle, comorbidities, environmental factors, and adiposity attenuated the association (HR comparing sleep duration SD of >60 vs. ≤60 min: 1.11; 95% CI 1.01, 1.22). The association was stronger among individuals with lower diabetes polygenic risk score (PRS; P interaction ≤ 0.0264) and longer sleep duration (P interaction ≤ 0.0009).</p>
CONCLUSIONS: Irregular sleep duration was associated with higher diabetes risk, particularly in individuals with a lower diabetes PRS and longer sleep duration.</p>
8 Authors
- Sina Kianersi
- Heming Wang
- Tamar Sofer
- Raymond Noordam
- Andrew Phillips
- Martin K Rutter
- Susan Redline
- Tianyi Huang
1 Application
| Application ID | Title |
|---|---|
| 85501 | Elucidating risk factors for and health impact of heart, lung, blood, and sleep disorders |
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