| Title: | Alcohol consumption and liver phenotype of individuals with alpha-1 antitrypsin deficiency |
| Journal: | Liver International |
| Published: | 19 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39031304/ |
| DOI: | https://doi.org/10.1111/liv.16044 |
Publication 12802
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Abstract
BACKGROUND AND AIMS: Alpha-1 antitrypsin deficiency is an inherited disorder caused by alpha-1 antitrypsin (AAT) mutations. We analysed the association between alcohol intake and liver-related parameters in individuals with the heterozygous/homozygous Pi*Z AAT variant (Pi*MZ/Pi*ZZ genotype) found in the United Kingdom Biobank and the European Alpha1 liver consortium.</p>
METHODS: Reported alcohol consumption was evaluated in two cohorts: (i) the community-based United Kingdom Biobank (17 145 Pi*MZ, 141 Pi*ZZ subjects, and 425 002 non-carriers [Pi*MM]); and (ii) the European Alpha1 liver consortium (561 Pi*ZZ individuals). Cohort (ii) included measurements of carbohydrate-deficient transferrin (CDT).</p>
RESULTS: In both cohorts, no/low alcohol intake was reported by >80% of individuals, while harmful consumption was rare (~1%). Among Pi*MM and Pi*MZ individuals from cohort (i), moderate alcohol consumption resulted in a <30% increased rate of elevated transaminases and ~50% increase in elevated gamma-glutamyl transferase values, while harmful alcohol intake led to an at least twofold increase in the abnormal levels. In Pi*ZZ individuals from both cohorts, moderate alcohol consumption had no marked impact on serum transaminase levels. Among Pi*ZZ subjects from cohort (ii) who reported no/low alcohol consumption, those with increased CDT levels more often had signs of advanced liver disease.</p>
CONCLUSIONS: Pi*MZ/Pi*ZZ genotype does not seem to markedly aggravate the hepatic toxicity of moderate alcohol consumption. CDT values might be helpful to detect alcohol consumption in those with advanced fibrosis. More data are needed to evaluate the impact of harmful alcohol consumption.</p>
21 Authors
- Malin Fromme
- Carolin V. Schneider
- Nurdan Guldiken
- Samira Amzou
- Yizhao Luo
- Monica Pons
- Joan Genesca
- Marc Miravitlles
- Katrine H. Thorhauge
- Mattias Mandorfer
- Johan Waern
- Kai Markus Schneider
- Jan Sperl
- Sona Frankova
- Marc Bartel
- Holger Zimmer
- Markus Zorn
- Aleksander Krag
- Alice Turner
- Christian Trautwein
- Pavel Strnad
1 Application
| Application ID | Title |
|---|---|
| 71300 | Elucidating host-environment interactions in gastrointestinal diseases |
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