| Title: | Association of triglyceride-glucose index with the risk of incident aortic dissection and aneurysm: a large-scale prospective cohort study in UK Biobank |
| Journal: | Cardiovascular Diabetology |
| Published: | 2 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39095822/ |
| DOI: | https://doi.org/10.1186/s12933-024-02385-x |
| URL: | http://dx.doi.org/10.1186/s12933-024-02385-x |
Publication 12724
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Abstract
BackgroundTriglyceride-glucose (TyG) index is an emerging surrogate indicator of insulin resistance, which has been demonstrated as a risk factor for various cardiovascular diseases including coronary syndrome, in-stent restenosis, and heart failure. However, association of TyG index with incident aortic dissection (AD) and aortic aneurysm (AA) remains to be investigated.MethodsThis study included 420,292 participants without baseline AD/AA from the large-scale prospective UK Biobank cohort. The primary outcome was incident AD/AA, comprising AD and AA. Multivariable-adjusted Cox proportional hazards regression models and restricted cubic spline (RCS) analyses were applied to assess the relationship between TyG index and the onset of AD/AA. In addition, the association between TyG index and incident AD/AA was examined within subgroups defined by age, gender, smoking status, drinking status, diabetes, hypertension, and BMI.ResultsOver a median follow-up period of 14.8 (14.1, 15.5) years, 3,481 AD/AA cases occurred. The incidence of AD/AA rose along with elevated TyG index. RCS curves showed a linear trend of TyG index with risk of incident AD/AA. TyG index was positively associated with risk of incident AD/AA after adjusting for age, gender, smoking status, drinking status, BMI, hypertension, LDL-c, and HbA1c, with adjusted HRs of 1.0 (reference), 1.20 (95% CI 1.08-1.35), 1.21 (95% CI 1.08-1.35), and 1.30 (95% CI 1.16-1.45) for TyG index quartiles 2, 3, and 4, respectively. Especially, participants in the highest TyG index quartile had highest risk of developing AA, with an adjusted HR of 1.35 (95% CI 1.20-1.52).ConclusionsTyG index is independently associated with a higher risk of incident AD/AA, indicating the importance of using TyG index for risk assessment of AD/AA, especially for AA.</p>
22 Keywords
- Adult
- Aged
- Aortic Aneurysm
- Aortic Dissection
- Biological Specimen Banks
- Biomarkers
- Blood Glucose
- Female
- Humans
- Incidence
- Insulin Resistance
- Male
- Middle Aged
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- Risk Assessment
- Risk Factors
- Time Factors
- Triglycerides
- UK Biobank
- United Kingdom
5 Authors
- Cuihong Tian
- Yequn Chen
- Binyi Xu
- Xuerui Tan
- Zhaowei Zhu
1 Application
| Application ID | Title |
|---|---|
| 84709 | Risk and prognosis factors of cardiovascular disease on different genetic background |
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