| Title: | Visual Impairment and Risk of Dementia: The UK Biobank Study |
| Journal: | American Journal of Ophthalmology |
| Published: | 22 Aug 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34433084/ |
| DOI: | https://doi.org/10.1016/j.ajo.2021.08.010 |
| URL: | https://www.medrxiv.org/content/medrxiv/early/2021/01/11/2021.01.08.21249188.full.pdf |
| Citations: | 13 (11 in last 2 years) as of 8 Aug 2024 |
Publication 12681
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Abstract
PURPOSE: To investigate the relationship between visual impairment (VI) and dementia in the UK Biobank Study.</p>
DESIGN: Prospective cohort study.</p>
METHODS: A total of 117,187 volunteers (aged 40-69 years) deemed free of dementia at baseline were included. Habitual distance visual acuity worse than 0.3 logMAR units in the better-seeing eye was used to define VI. The incident dementia was based on electronically linked hospital inpatient and death records.</p>
RESULTS: During a median follow-up of 5.96 years, the presence of VI was significantly associated with incident dementia (hazard ratio: 1.78; 95% confidence interval: 1.18-2.68; P = .006). There was a clear trend between the severity of VI and risk of dementia (P for trend = .002).</p>
CONCLUSIONS: We found VI was associated with increased risk of dementia, with a progressively greater risk among those with worse visual acuity. Our findings suggested that VI might be a modifiable risk factor for dementia and highlighted the potential value of VI elimination to delay the manifestation of dementia.</p>
10 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Dementia
- Humans
- Middle Aged
- Prospective Studies
- Risk Factors
- United Kingdom
- Vision Disorders
14 Authors
- Zhuoting Zhu
- Danli Shi
- Huan Liao
- Jason Ha
- Xianwen Shang
- Yu Huang
- Xueli Zhang
- Yu Jiang
- Longyue Li
- Honghua Yu
- Wenyi Hu
- Wei Wang
- Xiaohong Yang
- Mingguang He
1 Application
| Application ID | Title |
|---|---|
| 62443 | The eye and the brain |
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