| Title: | Associations of sleep and circadian phenotypes with COVID-19 susceptibility and hospitalization: an observational cohort study based on the UK Biobank and a two-sample Mendelian randomization study |
| Journal: | Sleep |
| Published: | 16 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35034128/ |
| DOI: | https://doi.org/10.1093/sleep/zsac003 |
| URL: | https://academic.oup.com/sleep/article-pdf/45/6/zsac003/43983083/zsac003.pdf |
| Citations: | 9 (7 in last 2 years) as of 8 Aug 2024 |
Publication 12603
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Abstract
STUDY OBJECTIVES: Sleep and circadian phenotypes are associated with several diseases. The present study aimed to investigate whether sleep and circadian phenotypes were causally linked with coronavirus disease 2019 (COVID-19)-related outcomes.</p>
METHODS: Habitual sleep duration, insomnia, excessive daytime sleepiness, daytime napping, and chronotype were selected as exposures. Key outcomes included positivity and hospitalization for COVID-19. In the observation cohort study, multivariable risk ratios (RRs) and their 95% confidence intervals (CIs) were calculated. Two-sample Mendelian randomization (MR) analyses were conducted to estimate the causal effects of the significant findings in the observation analyses. Odds ratios (ORs) and the corresponding 95% CIs were calculated and compared using the inverse variance weighting, weighted median, and MR-Egger methods.</p>
RESULTS: In the UK Biobank cohort study, both often excessive daytime sleepiness and sometimes daytime napping were associated with hospitalized COVID-19 (excessive daytime sleepiness [often vs. never]: RR = 1.24, 95% CI = 1.02-1.5; daytime napping [sometimes vs. never]: RR = 1.12, 95% CI = 1.02-1.22). In addition, sometimes daytime napping was also associated with an increased risk of COVID-19 susceptibility (sometimes vs. never: RR = 1.04, 95% CI = 1.01-1.28). In the MR analyses, excessive daytime sleepiness was found to increase the risk of hospitalized COVID-19 (MR IVW method: OR = 4.53, 95% CI = 1.04-19.82), whereas little evidence supported a causal link between daytime napping and COVID-19 outcomes.</p>
CONCLUSIONS: Observational and genetic evidence supports a potential causal link between excessive daytime sleepiness and an increased risk of COVID-19 hospitalization, suggesting that interventions targeting excessive daytime sleepiness symptoms might decrease severe COVID-19 rate.</p>
11 Keywords
- Biological Specimen Banks
- COVID-19
- Cohort Studies
- Disorders of Excessive Somnolence
- Genome-Wide Association Study
- Hospitalization
- Humans
- Mendelian Randomization Analysis
- Phenotype
- Sleep
- United Kingdom
11 Authors
- Zheran Liu
- Yaxin Luo
- Yonglin Su
- Zhigong Wei
- Ruidan Li
- Ling He
- Lianlian Yang
- Yiyan Pei
- Jianjun Ren
- Xingchen Peng
- Xiaolin Hu
1 Application
| Application ID | Title |
|---|---|
| 69718 | Multi-omic analyses of otorhinolaryngology-related disorders |
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