| Title: | Multivitamin/mineral supplementation and the risk of cardiovascular disease: a large prospective study using UK Biobank data |
| Journal: | European Journal of Nutrition |
| Published: | 18 Mar 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35301588/ |
| DOI: | https://doi.org/10.1007/s00394-022-02865-4 |
| Citations: | 5 (5 in last 2 years) as of 8 Aug 2024 |
Publication 12467
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Abstract
PurposeDespite the widespread use of multivitamin/mineral supplements, the effects of multivitamin/mineral on cardiovascular disease (CVD) remain inconclusive. We aimed to prospectively investigate how multivitamin/mineral use is associated with CVD.MethodsThis population-based cohort study included 465,278 men and women who participated in the UK Biobank and were free from CVD at baseline. Participants were enrolled between 2006 and 2010 and followed-up until the end of 2018. Data on supplement use including multivitamin/mineral were collected using self-reported questionnaires. Cox proportional hazards models were used to estimate the hazard ratios of CVD events in relation to multivitamin/mineral use.ResultsDuring the follow-up, we identified 25,772 cases of CVD events, 4754 cases of CVD mortality, 18,728 cases of coronary heart disease, 6726 cases of myocardial infarction, and 4561 cases of stroke. The multivariable-adjusted hazard ratios associated with multivitamin/mineral use were 0.96 (95% CI: 0.93, 0.99) for CVD events, 0.92 (0.86, 1.00) for CVD mortality, 0.96 (0.93, 0.99) for coronary heart disease, and 0.92 (0.86, 0.97) for myocardial infarction. Subgroup analysis suggested that multivitamin/mineral use was associated with a significantly lower risk of CVD events in participants aged < 60 years and in former and current smokers (P for interaction ≤ 0.01). Sensitivity analyses showed no substantial change in the results when we excluded participants who developed CVD events during the first 2 years of follow-up.ConclusionMultivitamin/mineral supplementation was associated with very modest reductions in CVD events. Age and smoking might modify these associations.</p>
15 Keywords
- Biological Specimen Banks
- Cardiovascular Diseases
- Cohort Studies
- Coronary Disease
- Dietary Supplements
- Female
- Follow-Up Studies
- Humans
- Male
- Minerals
- Myocardial Infarction
- Prospective Studies
- Risk Factors
- United Kingdom
- Vitamins
6 Authors
- Bizhong Che
- Chongke Zhong
- Ruijie Zhang
- Meng Wang
- Yonghong Zhang
- Liyuan Han
1 Application
| Application ID | Title |
|---|---|
| 52632 | Effect of economic, maternal, psycho-social, and health behavior factors, genetic susceptibility on pregnancies adverse outcomes |
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