| Title: | Human brain anatomy reflects separable genetic and environmental components of socioeconomic status |
| Journal: | Science Advances |
| Published: | 18 May 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35584223/ |
| DOI: | https://doi.org/10.1126/sciadv.abm2923 |
| URL: | https://biobank.ctsu.ox.ac.uk/crystal/crystal/docs/brain_mri.pdf |
| Citations: | 19 (13 in last 2 years) as of 8 Aug 2024 |
Publication 12367
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Abstract
Socioeconomic status (SES) correlates with brain structure, a relation of interest given the long-observed relations of SES to cognitive abilities and health. Yet, major questions remain open, in particular, the pattern of causality that underlies this relation. In an unprecedently large study, here, we assess genetic and environmental contributions to SES differences in neuroanatomy. We first establish robust SES-gray matter relations across a number of brain regions, cortical and subcortical. These regional correlates are parsed into predominantly genetic factors and those potentially due to the environment. We show that genetic effects are stronger in some areas (prefrontal cortex, insula) than others. In areas showing less genetic effect (cerebellum, lateral temporal), environmental factors are likely to be influential. Our results imply a complex interplay of genetic and environmental factors that influence the SES-brain relation and may eventually provide insights relevant to policy.</p>
8 Authors
- Hyeokmoon Kweon
- Gökhan Aydogan
- Alain Dagher
- Danilo Bzdok
- Christian C Ruff
- Gideon Nave
- Martha J Farah
- Philipp D Koellinger
1 Application
| Application ID | Title |
|---|---|
| 11425 | The Social Science Genetic Association Consortium |
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