| Title: | Circulating vitamin C and digestive system cancers: Mendelian randomization study |
| Journal: | Clinical Nutrition |
| Published: | 7 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35986965/ |
| DOI: | https://doi.org/10.1016/j.clnu.2022.07.040 |
| URL: | https://research-information.bris.ac.uk/files/337657585/PIIS0261561422002850.pdf |
| Citations: | 15 (13 in last 2 years) as of 8 Aug 2024 |
Publication 12281
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Abstract
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to utilize Mendelian randomization to decipher the potential causal associations of vitamin C with risk of digestive system cancers.</p>
METHODS: Ten genetic variants previously found to be significantly associated with circulating vitamin C were used as instrumental variables. Effect size estimates for the genetic associations of the vitamin C-associated genetic variants with six major malignancies of digestive system were obtained from the FinnGen (N = 309 154) and UK Biobank (N = 367 542) studies. Results from the two studies were combined using meta-analysis.</p>
RESULTS: Genetically predicted higher circulating vitamin C showed a suggestive association with lower risk of small intestine and colorectal cancer after accounting for multiple testing. The odds ratio per 1 standard deviation increment in circulating vitamin C was 0.55 (95% confidence interval 0.32-0.94; P = 0.029) for small intestine cancer and 0.84 (95% confidence interval 0.73-0.96; P = 0.013) for colorectal cancer. There was a suggestive association between genetically predicted higher circulating vitamin C with lower risk of liver cancer in FinnGen but no association in the meta-analysis (odds ratio 0.69; 95% CI 0.36-1.32; P = 0.265). Genetically predicted circulating vitamin C was not associated with cancers of the esophagus, stomach, or pancreas.</p>
CONCLUSION: This Mendelian randomization study indicates that vitamin C might play a role in the prevention of small intestine and colorectal cancer.</p>
8 Keywords
- Ascorbic Acid
- Colorectal Neoplasms
- Digestive System Neoplasms
- Humans
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Risk Factors
- Vitamins
7 Authors
- Susanna C. Larsson
- Amy M. Mason
- Mathew Vithayathil
- Paul Carter
- Siddhartha Kar
- Ju-Sheng Zheng
- Stephen Burgess
1 Application
| Application ID | Title |
|---|---|
| 29202 | Epidemiologic and genetic analyses of aging-associated diseases and mortality |
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