| Title: | Circulating fatty acids and risk of hepatocellular carcinoma and chronic liver disease mortality in the UK Biobank |
| Journal: | Nature Communications |
| Published: | 2 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38697980/ |
| DOI: | https://doi.org/10.1038/s41467-024-47960-8 |
Publication 12161
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Abstract
Nuclear magnetic resonance (NMR)-based plasma fatty acids are objective biomarkers of many diseases. Herein, we aim to explore the associations of NMR-based plasma fatty acids with the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD) mortality in 252,398 UK Biobank participants. Here we show plasma levels of n-3 poly-unsaturated fatty acids (PUFA) and n-6 PUFA are negatively associated with the risk of incident HCC [HRQ4vsQ1: 0.48 (95% CI: 0.33-0.69) and 0.48 (95% CI: 0.28-0.81), respectively] and CLD mortality [HRQ4vsQ1: 0.21 (95% CI: 0.13-0.33) and 0.15 (95% CI: 0.08-0.30), respectively], whereas plasma levels of saturated fatty acids are positively associated with these outcomes [HRQ4vsQ1: 3.55 (95% CI: 2.25-5.61) for HCC and 6.34 (95% CI: 3.68-10.92) for CLD mortality]. Furthermore, fibrosis stage significantly modifies the associations between PUFA and CLD mortality. This study contributes to the limited prospective evidence on the associations between plasma-specific fatty acids and end-stage liver outcomes.</p>
5 Authors
- Zhening Liu
- Hangkai Huang
- Jiarong Xie
- Yingying Xu
- Chengfu Xu
1 Application
| Application ID | Title |
|---|---|
| 79302 | Association between night shift work and NAFLD |
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