| Title: | Early-life exposure to tobacco, genetic susceptibility, and accelerated biological aging in adulthood |
| Journal: | Science Advances |
| Published: | 3 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38701212/ |
| DOI: | https://doi.org/10.1126/sciadv.adl3747 |
Publication 12157
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Abstract
Early-life tobacco exposure serves as a non-negligible risk factor for aging-related diseases. To understand the underlying mechanisms, we explored the associations of early-life tobacco exposure with accelerated biological aging and further assessed the joint effects of tobacco exposure and genetic susceptibility. Compared with those without in utero exposure, participants with in utero tobacco exposure had an increase in Klemera-Doubal biological age (KDM-BA) and PhenoAge acceleration of 0.26 and 0.49 years, respectively, but a decrease in telomere length of 5.34% among 276,259 participants. We also found significant dose-response associations between the age of smoking initiation and accelerated biological aging. Furthermore, the joint effects revealed that high-polygenic risk score participants with in utero exposure and smoking initiation in childhood had the highest accelerated biological aging. There were interactions between early-life tobacco exposure and age, sex, deprivation, and diet on KDM-BA and PhenoAge acceleration. These findings highlight the importance of reducing early-life tobacco exposure to improve healthy aging.</p>
12 Keywords
- Adult
- Aging
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Pregnancy
- Prenatal Exposure Delayed Effects
- Risk Factors
- Smoking
- Tobacco Products
9 Authors
- Feipeng Cui
- Linxi Tang
- Dankang Li
- Yudiyang Ma
- Jianing Wang
- Junqing Xie
- Binbin Su
- Yaohua Tian
- Xiaoying Zheng
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