| Title: | Impact of sarcopenic obesity on heart failure in people with type 2 diabetes and the role of metabolism and inflammation: A prospective cohort study |
| Journal: | Diabetes & Metabolic Syndrome Clinical Research & Reviews |
| Published: | 9 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38749096/ |
| DOI: | https://doi.org/10.1016/j.dsx.2024.103038 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 12121
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Abstract
AIMS: We aimed to prospectively evaluate the association of sarcopenic obesity (SO) with the incidence risk of heart failure (HF), and the mediating role of metabolomics and inflammation in people with type 2 diabetes (T2D).</p>
METHODS: 22,496 participants with T2D from the UK Biobank were included. SO was defined as the combination of obesity (body mass index ≥30 kg/m2) and sarcopenia (grip strength <27 kg in male or <16 kg in female). The incident HF was identified through linked hospital records. Cox proportional hazard regression models were used to estimate the associations. Mediation analysis was conducted to evaluate the mediating effect of the "metabolomic risk score" of HF, which was derived from 168 plasma metabolites through LASSO regression, and five inflammatory markers (e.g., C-reactive protein [CRP] level) on the aforementioned associations.</p>
RESULTS: 1946 (8.7 %) participants developed HF during a median follow-up of 12.0 years. Compared to participants with neither obesity nor sarcopenia, those with obesity & non-sarcopenia (hazard ratio [HR]: 1.80, 95 % confidence interval [CI]: 1.62, 2.00), sarcopenia & non-obesity (HR: 1.90, 95 % CI: 1.56, 2.31) and SO (HR: 2.29, 95 % CI: 1.92, 2.73) showed a higher risk of HF. The metabolomic risk score (20.0 %) and CRP (20.4 %) meditated this association.</p>
CONCLUSIONS: SO was associated with an increased risk of HF in people with T2D and metabolomics and inflammation partially mediated this association. Our findings suggest the importance of managing obesity and muscle strength simultaneously in preventing HF among people with T2D and shed light on the underlying mechanisms.</p>
8 Authors
- Xueqing Jia
- Liming Zhang
- Zhenqing Yang
- Xingqi Cao
- Zhao Yao
- Jingyun Zhang
- Zuobing Chen
- Zuyun Liu
1 Application
| Application ID | Title |
|---|---|
| 61856 | The role of biological aging in the effect of genetic and environmental factors on health outcomes |
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