| Title: | Association Between Ultra-Processed Foods Consumption and Leucocyte Telomere Length: A cross-sectional study of UK Biobank |
| Journal: | Journal of Nutrition |
| Published: | 11 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38735573/ |
| DOI: | https://doi.org/10.1016/j.tjnut.2024.05.001 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 12098
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Abstract
BACKGROUND: □ OBJECTIVES: This study aimed to investigate the association between consumption of ultraprocessed foods and leucocyte telomere length (LTL).</p>
METHODS: This cross-sectional study utilized data from the UK Biobank, including a total of 64,690 participants. LTL was measured using qPCR with natural logarithmic conversion and z-score normalization. Dietary data were collected through a 24-h recall questionnaire from 2009 to 2010. Ultraprocessed foods (UPFs) were identified using the NOVA food classification as either a continuous or a categorical variable. Multiple linear regression models were employed to analyze the association between UPF consumption and LTL.</p>
RESULTS: The included participants had an average age of 56.26 y, of whom 55.2% were female. After adjusting for demographic and health-related variables, LTL exhibited a decrease of 0.005 (95% CI: -0.007, -0.002) with 1 UPF serving increase. Compared with participants consuming ≤3.5 servings/d, those consuming 3.5 to <6 servings showed a shortening of LTL by 0.025 (95% CI: -0.046, -0.003). Participants consuming 6 to ≤8 servings/d and >8 servings/d had LTL shortening of 0.032 (95% CI: -0.054, -0.011) and 0.037 (95% CI: -0.060, -0.014), respectively (P for trend = 0.002). Subgroup analyses by UPF subclasses revealed that the consumption of ready-to-eat/heated food (β: -0.010; 95% CI: -0.016, -0.004), beans and potatoes (β: -0.027; 95% CI: -0.043, -0.012), animal-based products (β: -0.012; 95% CI: -0.020, -0.005), artificial sugar (β: -0.014; 95% CI:-0.025,-0.003), and beverages (β: -0.005; 95% CI: -0.009, -0.001) showed negative associations with LTL. Conversely, breakfast cereals (β: 0.022; 95% CI: 0.006, 0.038) and vegetarian alternatives (β: 0.056; 95% CI:0.026,0.085) showed positive correlations with LTL.</p>
CONCLUSIONS: Our study found that a higher consumption of total UPF was associated with a shorter LTL. However, some UPFs may be associated with longer LTL, depending on their nutritional composition.</p>
11 Authors
- Chunhao Li
- Yuchun Zhang
- Ke Zhang
- Hongna Fu
- Luyang Lin
- Guoyi Cai
- Xiaojun Zhang
- Xingfen Yang
- Zheqing Zhang
- Zhen Yang
- Bo Zhang
1 Application
| Application ID | Title |
|---|---|
| 92584 | Research on cardiovascular diseases, severe or acute diseases, chronic diseases and their related risk factors |
Enabling scientific discoveries that improve human health