| Title: | Dietary diversity score and the acceleration of biological aging: a population-based study of 88,039 participants |
| Journal: | The journal of nutrition health & aging |
| Published: | 28 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38810510/ |
| DOI: | https://doi.org/10.1016/j.jnha.2024.100271 |
Publication 11969
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Abstract
OBJECTIVES: Our study aimed to investigate the association of dietary diversity score (DDS), as reflected by five dietary categories, with biological age acceleration.</p>
DESIGN: A cross-sectional study.</p>
SETTING AND PARTICIPANTS: This study included 88,039 individuals from the UK Biobank.</p>
METHODS: Biological age (BA) was assessed using Klemerae-Doubal (KDM) and PhenoAge methods. The difference between BA and chronological age represents the age acceleration (AgeAccel), termed as "KDMAccel" and "PhenoAgeAccel". AgeAccel > 0 indicates faster aging. Generalized linear regression models were performed to assess the associations of DDS with AgeAccel. Similar analyses were performed for the five dietary categories.</p>
RESULTS: After adjusting for multiple variables, DDS was inversely associated with KDMAccel (βHigh vs Low= -0.403, 95%CI: -0.492 to -0.314, P < 0.001) and PhenoAgeAccel (βHigh vs Low= -0.545, 95%CI: -0.641 to -0.450, P < 0.001). Each 1-point increment in the DDS was associated with a 4.4% lower risk of KDMAccel and a 5.6% lower risk of PhenoAgeAccel. The restricted cubic spline plots demonstrated a non-linear dose-response association between DDS and the risk of AgeAccel. The consumption of grains (βKDMAccel = -0.252, βPhenoAgeAccel = -0.197), vegetables (βKDMAccel = -0.044, βPhenoAgeAccel = -0.077) and fruits (βKDMAccel = -0.179, βPhenoAgeAccel = -0.219) was inversely associated with the two AgeAccel, while meat and protein alternatives (βKDMAccel = 0.091, βPhenoAgeAccel = 0.054) had a positive association (All P < 0.001). Stratified analysis revealed stronger accelerated aging effects in males, smokers, and drinkers. A strengthening trend in the association between DDS and AgeAccel as TDI quartiles increased was noted.</p>
CONCLUSIONS: This study suggested that food consumption plays a role in aging process, and adherence to a higher diversity dietary is associated with the slowing down of the aging process.</p>
14 Authors
- Ye Liu
- Meijuan Kang
- Wenming Wei
- Jingni Hui
- Yifan Gou
- Chen Liu
- Ruixue Zhou
- Bingyi Wang
- Panxing Shi
- Huan Liu
- Bolun Cheng
- Yumeng Jia
- Yan Wen
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
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