| Title: | Risks of cutaneous immune-related adverse events in long COVID: Multinational cohort studies in South Korea, Japan, and the UK |
| Journal: | Journal of Medical Virology |
| Published: | 14 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38874226/ |
| DOI: | https://doi.org/10.1002/jmv.29740 |
Publication 11853
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Abstract
Previous research has not investigated the persistent cutaneous immune-related adverse events (cirAEs) related to long COVID to investigate the long-term sequelae. This multinational study, using a propensity-matched overlap weighting method, utilizes large national claims-based cohorts, using ICD-10 code diagnosis, focusing on patients aged ≥20 years from three countries: South Korean, Japanese, and the British cohorts. To estimate the risk of cirAEs in long COVID, the persistence or emergence of cirAEs occurring 4 weeks after the initial SARS-CoV-2 infection, we employed a Cox proportional hazard regression model. The Korean cohort (n = 5,937,373; mean age 49.2 years [SD: 13.2]), the Japanese cohort (n = 4,307,587; 42.5 years [13.6]), and the UK cohort (n = 395,435; 71.0 years [8.07]) were presented. An increased risk of cirAEs in long COVID was observed (HR, 1.10; 95% CI, 1.06-1.14) in Korean cohort, while a similar association was observed in Japanese and UK cohorts. The long-term risk of cirAEs in long COVID was higher in more severe COVID-19 cases (1.31; 1.22-1.39). Unlike the increased risk of cirAEs in long COVID, COVID-19 vaccination attenuated the risk, especially with two or more doses (1.03; 0.95-1.11) or heterologous regimens (0.98; 0.76-1.27). The time attenuation effect indicated a sustained risk for up to 6 months postinfection (<3 months: 1.13 [1.07-1.19]; 3-6 months: 1.14 [1.06-1.22]). SARS-CoV-2 infection is associated with an increased risk of cirAEs in the aspect of long COVID. Vaccination might reduce this risk, highlighting the need for preventive strategies in long COVID management.</p>
16 Authors
- Hyejun Kim
- Seoyeon Kyung
- Jaeyu Park
- Hojae Lee
- Myeongcheol Lee
- Lee Smith
- Masoud Rahmati
- Ju-Young Shin
- Jiseung Kang
- Louis Jacob
- Nikolaos G. Papadopoulos
- Sang Youl Rhee
- Jinseok Lee
- Hyeon Jin Kim
- Hayeon Lee
- Dong Keon Yon
1 Application
| Application ID | Title |
|---|---|
| 94075 | Genetic and environmental risk factors for poor respiratory health in adults: comparison of two mega-cohorts in different countries (Korea and UK). |
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