| Title: | Sleep and liver function biomarkers in relation to risk of incident liver cancer: a nationwide prospective cohort study |
| Journal: | BMC Medicine |
| Published: | 24 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38915009/ |
| DOI: | https://doi.org/10.1186/s12916-024-03440-w |
| URL: | http://dx.doi.org/10.1186/s12916-024-03440-w |
Publication 11805
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Abstract
BackgroundTo assess the largely undetermined separate and joint effects of sleep and liver function biomarkers on liver cancer.MethodsData of 356,894 participants without cancer at baseline in the UK Biobank were analyzed. Sleep score was evaluated using five sleep traits (sleep duration, chronotype, insomnia, snoring, and excessive daytime sleepiness) and dichotomized into healthy or unhealthy sleep. Circulating liver function biomarkers were measured. Cox proportional hazard model was performed to investigate the independent and joint associations of sleep and liver function biomarkers with liver cancer incidence.ResultsAfter a median follow-up time of 13.1 years, 394 cases of incident liver cancer were documented. The multivariable-adjusted hazard ratio (HR) for liver cancer was 1.46 (95% confidence interval: 1.15-1.85) associated with unhealthy sleep (vs. healthy sleep), and was 1.17 (1.15-1.20), 1.20 (1.18-1.22), 1.69 (1.47-1.93), 1.06 (1.06-1.07), 1.08 (1.07-1.09), 1.81 (1.37-2.39), or 0.29 (0.18-0.46) associated with each 10-unit increase in alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBIL), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), total protein (TP), or albumin (ALB), respectively. Individuals with unhealthy sleep and high (≥ median) ALT, AST, TBIL, GGT, ALP, or TP or low (< median) ALB level had the highest HR of 3.65 (2.43-5.48), 4.03 (2.69-6.03), 1.97 (1.40-2.77), 4.69 (2.98-7.37), 2.51 (1.75-3.59), 2.09 (1.51-2.89), or 2.22 (1.55-3.17) for liver cancer, respectively. Significant additive interaction of unhealthy sleep with high TP level on liver cancer was observed with relative excess risk due to an interaction of 0.80 (0.19-1.41).ConclusionsUnhealthy sleep was associated with an increased risk of liver cancer, especially in participants with lower ALB levels or higher levels of ALT, AST, TBIL, GGT, ALP, or particularly TP.</p>
15 Keywords
- Adult
- Aged
- Biomarkers
- Female
- Humans
- Incidence
- Liver
- Liver Function Tests
- Liver Neoplasms
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Sleep
- United Kingdom
12 Authors
- Jiahao Song
- Lieyang Fan
- Da Shi
- Xuefeng Lai
- Hao Wang
- Wei Liu
- Linling Yu
- Ruyi Liang
- Yongfang Zhang
- Shuhui Wan
- Yueru Yang
- Bin Wang
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
Enabling scientific discoveries that improve human health