| Title: | The impact of lifestyle on cardiovascular risk in patients with gout: a population-based cohort study |
| Journal: | European Heart Journal - Quality of Care and Clinical Outcomes |
| Published: | 26 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38925656/ |
| DOI: | https://doi.org/10.1093/ehjqcco/qcae048 |
Publication 11783
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Abstract
AIMS: Gout is associated with a significant burden of cardiovascular disease. The aim of this study was to evaluate the impact of a favorable lifestyle on incident cardiovascular events in patients with gout.</p>
METHODS: We identified 9 110 patients with gout from the UK Biobank cohort based on self-report and/or hospital diagnostic codes. Lifestyle behaviors, including smoking status, physical activity, obesity, and diet, were categorized into three patterns: favorable (3-4 healthy factors), intermediate (2 healthy factors), and unfavorable (0-1 healthy factor). The cardiovascular risk of participants with and without gout was estimated based on their serum uric acid levels and lifestyle patterns.</p>
RESULTS: Among 9 110 patients with gout and 457 596 participants without gout, the median follow-up duration was 8.9 years. The incidence rate of cardiovascular disease was significantly higher in the gout population than in the non-gout population (11.38 vs 5.49 per 1000 person-years). The gout population consistently exhibited a high cardiovascular risk, irrespective of uric acid levels, whereas a positive correlation was observed between uric acid levels and cardiovascular risk in the non-gout population. Adopting a favorable lifestyle pattern was associated with a lower risk of cardiovascular disease in both gout and non-gout populations. Across all categories of uric acid, a favorable lifestyle was found to reduce cardiovascular risk in patients with gout.</p>
CONCLUSION: Patients with gout remain at high risk of developing cardiovascular disease despite having normal uric acid levels. Lifestyle modifications may represent an effective and cost-efficient therapeutic approach for preventing cardiovascular events in this population.</p>
8 Authors
- Seung Min Jung
- Sang-Hyuk Jung
- Su-Nam Lee
- Jin A Choi
- Dokyoon Kim
- Hong-Hee Won
- Ki-Jo Kim
- Jae-Seung Yun
1 Application
| Application ID | Title |
|---|---|
| 67855 | Development and validation of a comprehensive predictive model for diabetes complications |
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