| Title: | The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study |
| Journal: | Scientific Reports |
| Published: | 28 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38942746/ |
| DOI: | https://doi.org/10.1038/s41598-024-58007-9 |
Publication 11771
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Abstract
Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derived sleep traits. Mendelian randomization (MR) studies support an effect of self-reported insomnia, but not others, on glycated haemoglobin (HbA1c). To explore potential effects, we used MR methods to assess effects of accelerometer-derived sleep traits (duration, mid-point least active 5-h, mid-point most active 10-h, sleep fragmentation, and efficiency) on HbA1c/glucose in European adults from the UK Biobank (UKB) (n = 73,797) and the MAGIC consortium (n = 146,806). Cross-trait linkage disequilibrium score regression was applied to determine genetic correlations across accelerometer-derived, self-reported sleep traits, and HbA1c/glucose. We found no causal effect of any accelerometer-derived sleep trait on HbA1c or glucose. Similar MR results for self-reported sleep traits in the UKB sub-sample with accelerometer-derived measures suggested our results were not explained by selection bias. Phenotypic and genetic correlation analyses suggested complex relationships between self-reported and accelerometer-derived traits indicating that they may reflect different types of exposure. These findings suggested accelerometer-derived sleep traits do not affect HbA1c. Accelerometer-derived measures of sleep duration and quality might not simply be 'objective' measures of self-reported sleep duration and insomnia, but rather captured different sleep characteristics.</p>
23 Authors
- Junxi Liu
- Rebecca C. Richmond
- Emma L. Anderson
- Jack Bowden
- Ciarrah-Jane S. Barry
- Hassan S. Dashti
- Iyas S. Daghlas
- Jacqueline M. Lane
- Simon D. Kyle
- Céline Vetter
- Claire L. Morrison
- Samuel E. Jones
- Andrew R. Wood
- Timothy M. Frayling
- Alison K. Wright
- Matthew J. Carr
- Simon G. Anderson
- Richard A. Emsley
- David W. Ray
- Michael N. Weedon
- Richa Saxena
- Martin K. Rutter
- Deborah A. Lawlor
1 Application
| Application ID | Title |
|---|---|
| 6818 | Sleep and chronotype and their causal links with cardiometabolic and chronic inflammatory diseases |
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