| Title: | Night shift work and myocardial infarction in the UK Biobank |
| Journal: | Occupational Medicine |
| Published: | 29 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38944843/ |
| DOI: | https://doi.org/10.1093/occmed/kqae045 |
Publication 11763
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Shift work has become popular along with adverse effects such as disrupted biological rhythms, metabolic changes, sleep disorders and myocardial infarction. Studies have shown a link between myocardial infarction and shift work, but evidence is still lacking.</p>
AIMS: We aim to explore the association between present and past shift work and risk of myocardial infarction in a large population of European workers.</p>
METHODS: We analysed data from the UK Biobank with >500 000 participants and an average 12-year follow-up duration. Cox proportional hazard models were employed to analyse the relationship between present shift work (n = 265 064), lifetime duration or frequency of shift work (n = 71 428) and the risk of myocardial infarction, as well as the association between rest day during shift work and myocardial infarction incidents in night shift workers (n = 14 588).</p>
RESULTS: Night shift workers had a higher risk of myocardial infarction compared to day workers, including 'shift but never/rarely night shifts' (hazard ratio [HR] = 1.09, 95% confidence interval [CI] 1.00-1.20), 'some night shifts' (HR = 1.13, 95% CI 1.01-1.27) and 'usual/permanent night shifts' (HR = 1.21, 95% CI 1.07-1.37), respectively. Similarly, higher frequency and longer duration of night shift work were associated with the increased risk of myocardial infarction (<10 years: HR = 1.20, 95% CI 1.01-1.42; ≥10 years: HR = 1.51, 95% CI 1.28-1.77; or an average of more than eight nights per month: HR = 1.45, 95% CI 1.23-1.71). However, longer rest days couldn't decrease myocardial infarction risk compared to those who rest 1 day.</p>
CONCLUSIONS: Present and lifetime exposure to night shifts were associated with a risk of myocardial infarction and did not benefit from longer rest days.</p>
7 Authors
- M J Yang
- Z W Jia
- E Wang
- J C Li
- A M Tang
- Z B Song
- Z Zhang
1 Application
| Application ID | Title |
|---|---|
| 82640 | the determinants of sleep health and its composite influence on age-related cardiometabolic disease and neurodegenerative disease |
Enabling scientific discoveries that improve human health