| Title: | Prospective cohort studies underscore the association of abnormal glycemic measures with all-cause and cause-specific mortalities |
| Journal: | iScience |
| Published: | 8 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39021808/ |
| DOI: | https://doi.org/10.1016/j.isci.2024.110233 |
| URL: | http://dx.doi.org/10.1016/j.isci.2024.110233 |
Publication 11749
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
The role of fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and triglyceride-glucose index (TyG index) in predicting all-cause and cause-specific mortalities remains elusive. This study included 384,420 adults from the Shanghai cohort and the UK Biobank (UKB) cohort. After multivariable adjustment in the Cox models, FPG ≥7.0 mmol/L or HbA1c ≥ 6.5% increased the risk of all-cause mortality, FPG ≥5.6 mmol/L or HbA1c ≥ 6.5% increased CVD-related mortality, and higher or lower TyG index increased all-cause and CVD-related mortalities in the Shanghai cohort; FPG ≥5.6 mmol/L, HbA1c ≥ 5.7%, TyG index <8.31 or ≥9.08 increased the risks of all-cause, CVD-related, and cancer-related mortalities in the UKB cohort. FPG or HbA1c increased the discrimination of the conventional risk model in predicting all-cause and CVD-related mortalities in both cohorts. Thus, increased levels of FPG and HbA1c and U-shaped TyG index increase the risks of all-cause especially CVD-related mortalities.</p>
11 Authors
- Juzhong Ke
- Xiaonan Ruan
- Wenbin Liu
- Xiaolin Liu
- Kang Wu
- Hua Qiu
- Xiaonan Wang
- Yibo Ding
- Xiaojie Tan
- Zhitao Li
- Guangwen Cao
1 Application
| Application ID | Title |
|---|---|
| 101971 | Effects of physical activity, environmental exposure, and multilevel biomarkers including genetic predisposition and inflammatory markers on the cancer occurrence and all-cause / cancer mortalities |
Enabling scientific discoveries that improve human health