| Title: | Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank |
| Journal: | Nature Mental Health |
| Published: | 4 Jul 2024 |
| DOI: | https://doi.org/10.1038/s44220-024-00272-8 |
Publication 11717
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Abstract
Mental health conditions are characterized by higher-order transdiagnostic factor structures, which may contribute to the high levels of comorbidity observed in psychopathology. However, the phenotypic and genetic structures of various psychopathology diagnoses may differ, raising questions about the validity and utility of these factors. Here we study the phenotypic and genetic factor structures of ten psychiatric conditions using UK Biobank and public genomic data. Although the factor structure of psychopathology was generally genetically and phenotypically consistent, conditions related to externalizing (for example, alcohol use disorder) and compulsivity (for example, eating disorders) exhibited cross-level disparities in their relationships with other conditions, possibly due to environmental influences. Domain-level factors, especially thought disorder and internalizing factors, were more informative than a general psychopathology factor in genome-wide association and polygenic index analyses. Collectively, our findings enhance the understanding of comorbidity and shared etiology, highlight the intricate interplay between genes and environment, and offer guidance for psychiatric research using polygenic indices.</p>
9 Authors
- Camille M. Williams
- Hugo Peyre
- Tobias Wolfram
- Younga H. Lee
- Jakob Seidlitz
- Tian Ge
- Jordan W. Smoller
- Travis T. Mallard
- Franck Ramus
1 Application
| Application ID | Title |
|---|---|
| 46007 | Brain allometry and asymmetries as intermediate phenotypes between genetic and environmental factors, and cognitive function and mental health |
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