| Title: | Cigarette smoking and risk of severe infectious respiratory diseases in UK adults: 12-year follow-up of UK biobank |
| Journal: | Journal of Public Health |
| Published: | 22 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37347589/ |
| DOI: | https://doi.org/10.1093/pubmed/fdad090 |
| URL: | https://academic.oup.com/jpubhealth/advance-article-pdf/doi/10.1093/pubmed/fdad090/50678655/fdad090.pdf |
Publication 11584
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: The relevance of tobacco smoking for infectious respiratory diseases (IRD) is uncertain. We investigated the associations of cigarette smoking with severe IRD resulting in hospitalization or death in UK adults.</p>
METHODS: We conducted a prospective study of cigarette smoking and risk of severe IRD in UK Biobank. The outcomes included pneumonia, other acute lower respiratory tract infections (OA-LRTI) and influenza. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) of severe IRD associated with smoking habits after adjusting for confounding factors.</p>
RESULTS: Among 341 352 participants with no prior history of major chronic diseases, there were 12 384 incident cases with pneumonia, 7054 with OA-LRTI and 795 with influenza during a 12-year follow-up. Compared with non-smokers, current smoking was associated with ⁓2-fold higher rates of severe IRD (HR 2.40 [2.27-2.53] for pneumonia, 1.99 [1.84-2.14] for OA-LRTI and 1.82 [95% confidence interval: 1.47-2.24] for influenza). Incidence of all severe IRDs were positively associated with amount of cigarettes smoked. The HRs for each IRD (except influenza) also declined with increasing duration since quitting.</p>
CONCLUSIONS: Current cigarette smoking was positively associated with higher rates of IRD and the findings extend indications for tobacco control measures and vaccination of current smokers for prevention of severe IRD.</p>
5 Authors
- Luke J McGeoch
- Stephanie Ross
- M Sofia Massa
- Sarah Lewington
- Robert Clarke
1 Application
| Application ID | Title |
|---|---|
| 31461 | Major risk factors for Cardiovascular Disease |
Enabling scientific discoveries that improve human health