| Title: | Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups |
| Journal: | Nature Communications |
| Published: | 2 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37268629/ |
| DOI: | https://doi.org/10.1038/s41467-023-38990-9 |
| URL: | https://escholarship.org/uc/item/4br368g3 |
| Citations: | 7 (7 in last 2 years) as of 8 Aug 2024 |
Publication 11530
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Abstract
We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs developed from multiple independent GWAS, perform best across all race/ethnic backgrounds. Stratified analysis in All of Us shows that PRSs are better predictive of BP in females compared to males, individuals without obesity, and middle-aged (40-60 years) compared to older and younger individuals.</p>
10 Keywords
- Blood Pressure
- Ethnicity
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Multifactorial Inheritance
- Population Health
- Risk Factors
43 Authors
- Nuzulul Kurniansyah
- Matthew O. Goodman
- Alyna T. Khan
- Jiongming Wang
- Elena Feofanova
- Joshua C. Bis
- Kerri L. Wiggins
- Jennifer E. Huffman
- Tanika Kelly
- Tali Elfassy
- Xiuqing Guo
- Walter Palmas
- Henry J. Lin
- Shih-Jen Hwang
- Yan Gao
- Kendra Young
- Gregory L. Kinney
- Jennifer A. Smith
- Bing Yu
- Simin Liu
- Sylvia Wassertheil-Smoller
- JoAnn E. Manson
- Xiaofeng Zhu
- Yii-Der Ida Chen
- I-Te Lee
- C. Charles Gu
- Donald M. Lloyd-Jones
- Sebastian Zöllner
- Myriam Fornage
- Charles Kooperberg
- Adolfo Correa
- Bruce M. Psaty
- Donna K. Arnett
- Carmen R. Isasi
- Stephen S. Rich
- Robert C. Kaplan
- Susan Redline
- Braxton D. Mitchell
- Nora Franceschini
- Daniel Levy
- Jerome I. Rotter
- Alanna C. Morrison
- Tamar Sofer
1 Application
| Application ID | Title |
|---|---|
| 81097 | Polygenic risk scores and causal contributions between cardiovascular disease and Alzheimer's disease |
Enabling scientific discoveries that improve human health