| Title: | Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer. |
| Journal: | Cancer Epidemiology Biomarkers & Prevention |
| Published: | 16 May 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37195052/ |
| DOI: | https://doi.org/10.1158/1055-9965.epi-23-0101 |
| URL: | https://doi.org/10.1158/1055-9965.23516024 |
Publication 11451
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Abstract
BACKGROUND: Risk factors contributing to more than 10-fold increase in esophageal cancer in the last 50 years remain underexplored. We aim to examine the associations of sleep behaviors with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (ESCC).</p>
METHODS: We prospectively assessed the associations between sleep behaviors (chronotype, duration, daytime napping, daytime sleepiness, snoring, and insomnia) and EAC and ESCC risk in 393,114 participants in the UK Biobank (2006-2016). Participants with 0, 1, and ≥2 unhealthy behaviors, including sleep <6 or >9 h/d, daytime napping, and usual daytime sleepiness were classified as having a good, intermediate, and poor sleep. For EAC, we also examined interactions with polygenic risk score (PRS). Cox models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI).</p>
RESULTS: We documented 294 incident EAC and 95 ESCC. Sleep >9 h/d (HR, 2.05; 95% CI, 1.18-3.57) and sometimes daytime napping (HR, 1.36; 95% CI, 1.06-1.75) were individually associated with increased EAC risk. Compared with individuals with good sleep, those with intermediate sleep had a 47% (HR, 1.47; 95% CI, 1.13-1.91) increased EAC risk, and those with poor sleep showed an 87% (HR, 1.87; 95% CI, 1.24-2.82) higher risk (Ptrend < 0.001). The elevated risks for EAC were similar within strata of PRS (Pinteraction = 0.884). Evening chronotype was associated with elevated risk of ESCC diagnosed after 2 years of enrollment (HR, 2.79; 95% CI, 1.32-5.88).</p>
CONCLUSIONS: Unhealthy sleep behaviors were associated with an increased risk of EAC, independent of genetic risk.</p>
IMPACT: Sleep behaviors may serve as modifiable factors for the prevention of EAC.</p>
12 Authors
- Xiaoyan Wang
- Ruiyi Tian
- Xiaoyu Zong
- Myung Sik Jeon
- Jingqin Luo
- Graham A Colditz
- Jean S Wang
- Konstantinos K Tsilidis
- Yo-El S Ju
- Ramaswamy Govindan
- Varun Puri
- Yin Cao
Enabling scientific discoveries that improve human health