| Title: | Association between accelerometer-measured amplitude of rest-activity rhythm and future health risk: a prospective cohort study of the UK Biobank |
| Journal: | The Lancet Healthy Longevity |
| Published: | 1 May 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37148892/ |
| DOI: | https://doi.org/10.1016/s2666-7568(23)00056-9 |
| URL: | http://www.thelancet.com/article/S2666756823000569/pdf |
| Citations: | 14 (14 in last 2 years) as of 8 Aug 2024 |
Publication 11394
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Abstract
BACKGROUND: The health effects of rest-activity rhythm are of major interest to public health, but its associations with health outcomes remain elusive. We aimed to examine the associations between accelerometer-measured rest-activity rhythm amplitude and health risks among the general UK population.</p>
METHODS: We did a prospective cohort analysis of UK Biobank participants aged 43-79 years with valid wrist-worn accelerometer data. Low rest-activity rhythm amplitude was defined as the first quintile of relative amplitude; all other quintiles were classified as high rest-activity rhythm amplitude. Outcomes of interest were defined using International Classification of Diseases 10th Revision codes and consisted of incident cancer and cardiovascular, infectious, respiratory, and digestive diseases, and all-cause and disease-specific (cardiovascular, cancer, and respiratory) mortality. Participants with a current diagnosis of any outcome of interest were excluded. We assessed the associations between decreased rest-activity rhythm amplitude and outcomes using Cox proportional hazards models.</p>
FINDINGS: Between June 1, 2013, and Dec 23, 2015, 103 682 participants with available raw accelerometer data were enrolled. 92 614 participants (52 219 [56·4%] women and 40 395 [42·6%] men) with a median age of 64 years (IQR 56-69) were recruited. Median follow-up was 6·4 years (IQR 5·8-6·9). Decreased rest-activity rhythm amplitude was significantly associated with increased incidence of cardiovascular diseases (adjusted hazard ratio 1·11 [95% CI 1·05-1·16]), cancer (1·08 [1·01-1·16]), infectious diseases (1·31 [1·22-1·41]), respiratory diseases (1·26 [1·19-1·34]), and digestive diseases (1·08 [1·03-1·14]), as well as all-cause mortality (1·54 [1·40-1·70]) and disease-specific mortality (1·73 [1·34-2·22] for cardiovascular diseases, 1·32 [1·13-1·55] for cancer, and 1·62 [1·25-2·09] for respiratory diseases). Most of these associations were not modified by age older than 65 years or sex. Among 16 accelerometer-measured rest-activity parameters, low rest-activity rhythm amplitude had the strongest or second- strongest associations with nine health outcomes.</p>
INTERPRETATION: Our results suggest that low rest-activity rhythm amplitude might contribute to major health outcomes and provide further evidence to promote risk-modifying strategies associated with rest-activity rhythm to improve health and longevity.</p>
FUNDING: National Natural Science Foundation of China and China Postdoctoral Science Foundation.</p>
16 Authors
- Hongliang Feng
- Lulu Yang
- Sizhi Ai
- Yue Liu
- Weijie Zhang
- Binbin Lei
- Jie Chen
- Yaping Liu
- Joey W Y Chan
- Ngan Yin Chan
- Xiao Tan
- Ningjian Wang
- Christian Benedict
- Fujun Jia
- Yun Kwok Wing
- Jihui Zhang
1 Application
| Application ID | Title |
|---|---|
| 58082 | Using Mendelian Randomization to investigate the causal associations between rest-activity patterns and common diseases |
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