| Title: | Associations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participants |
| Journal: | BMC Medicine |
| Published: | 3 Apr 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37013578/ |
| DOI: | https://doi.org/10.1186/s12916-023-02793-y |
| URL: | https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-023-02793-y |
| Citations: | 20 (20 in last 2 years) as of 8 Aug 2024 |
Publication 11280
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Abstract
Abstract</p>
BackgroundAlthough non-alcoholic fatty liver disease (NAFLD) is linked to inflammation, whether an inflammatory diet increases the risk of NAFLD is unclear. This study aimed to examine the association between the Energy-adjusted Diet Inflammatory Index (E-DII) score and severe NAFLD using UK Biobank.MethodsThis prospective cohort study included 171,544 UK Biobank participants. The E-DII score was computed using 18 food parameters. Associations between the E-DII and incident severe NAFLD (defined as hospital admission or death) were first investigated by E-DII categories (very/moderately anti-inflammatory [E-DII < − 1], neutral [E-DII − 1 to 1] and very/moderately pro-inflammatory [E-DII > 1]) using Cox proportional hazard models. Nonlinear associations were investigated using penalised cubic splines fitted into the Cox proportional hazard models. Analyses were adjusted for sociodemographic, lifestyle and health-related factors.ResultsOver a median follow-up of 10.2 years, 1489 participants developed severe NAFLD. After adjusting for confounders, individuals in the very/moderately pro-inflammatory category had a higher risk (HR: 1.19 [95% CI: 1.03 to 1.38]) of incident severe NAFLD compared with those in the very/moderately anti-inflammatory category. There was some evidence of nonlinearity between the E-DII score and severe NAFLD.ConclusionsPro-inflammatory diets were associated with a higher risk of severe NAFLD independent of confounders such as the components of the metabolic syndrome. Considering there is no recommended treatment for the disease, our findings suggest a potential means to lower the risk of NAFLD.</p>
12 Authors
- Fanny Petermann-Rocha
- Michael D. Wirth
- Jirapitcha Boonpor
- Solange Parra-Soto
- Ziyi Zhou
- John C. Mathers
- Katherine Livingstone
- Ewan Forrest
- Jill P. Pell
- Frederick K. Ho
- James R. Hébert
- Carlos Celis-Morales
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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