| Title: | The Association of Physical Activity Behaviors and Patterns With Aging Acceleration: Evidence From the UK Biobank |
| Journal: | The Journals of Gerontology Series A |
| Published: | 23 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36815559/ |
| DOI: | https://doi.org/10.1093/gerona/glad064 |
| URL: | https://academic.oup.com/biomedgerontology/advance-article-pdf/doi/10.1093/gerona/glad064/49313029/glad064.pdf |
Publication 11126
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Abstract
Prior evidence suggests that physical activity may reduce the risk of multiple diseases and mortality. However, whether and how physical activity affects the aging process remains largely unexplored. We included 284 479 UK Biobank participants and computed leukocyte telomere length (LTL) deviation (ie, the difference between genetically determined and observed LTL) and biological age acceleration (defined as the discrepancy between the phenotypic age of a person and the average phenotypic age in the cohort of individuals with the same age and sex) as the indexes for aging acceleration. Linear and logistic models were used to estimate the associations of self-reported physical activity items and patterns (identified by principal component analysis), as well as accelerometer-assessed physical activity, with aging acceleration. Analyses of physical activity patterns indicated, a higher level of adherence to activity patterns predominated by strenuous sports, other exercises, walking for pleasure, heavy and light housework, and public transportation use was associated with a lower risk of aging acceleration, whereas a higher level of adherence to patterns predominated by job-related activities was associated with a higher risk of aging acceleration. Analysis among 62 418 participants with accelerometer-measured physical activity corroborated these results. Physical activity, such as strenuous sports and other exercises in leisure time and the use of public transportation, was associated with reduced biological aging. Besides highlighting the importance of engaging in physical activity for healthy aging, our results provide further evidence for the beneficial effect of physical activity on the telomere attrition process.</p>
11 Authors
- Jianwei Zhu
- Yao Yang
- Yu Zeng
- Xin Han
- Wenwen Chen
- Yao Hu
- Yuanyuan Qu
- Huazhen Yang
- Unnur A Valdimarsdóttir
- Fang Fang
- Huan Song
1 Application
| Application ID | Title |
|---|---|
| 54803 | Deciphering complex traits - phenotypic and genetic associations between traits in the UK Biobank Cohort |
Enabling scientific discoveries that improve human health