| Title: | Associations Between HbA1c Across the Normal Range, Diagnosed, and Undiagnosed Diabetes and Retinal Layer Thickness in UK Biobank Cohort |
| Journal: | Translational Vision Science & Technology |
| Published: | 16 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36795065/ |
| DOI: | https://doi.org/10.1167/tvst.12.2.25 |
| URL: | https://tvst.arvojournals.org/arvo/content_public/journal/tvst/938623/i2164-2591-12-2-25_1676526751.68148.pdf |
| Citations: | 2 (2 in last 2 years) as of 8 Aug 2024 |
Publication 11098
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Abstract
Purpose: The purpose of this study was to investigate the association between glycated hemoglobin (HbA1c) levels and retinal sub-layer thicknesses in people with and without diabetes.</p>
Methods: We included 41,453 UK Biobank participants aged 40 to 69 years old. Diabetes status was defined by self-report of diagnosis or use of insulin. Participants were categorized into groups: (1) those with HbA1c <48 mmol/mol were subdivided into quintiles according to normal range of HbA1c; (2) those previously diagnosed with diabetes with no evidence of diabetic retinopathy; and (3) undiagnosed diabetes: >48 mmol/mol. Total macular and retinal sub-layer thicknesses were derived from spectral-domain optical coherence tomography (SD-OCT) images. Multivariable linear regression was used to evaluate the associations between diabetes status and retinal layer thickness.</p>
Results: Compared with participants in the second quintile of the normal HbA1c range, those in the fifth quintile had a thinner photoreceptor layer thickness (-0.33 µm, P = 0.006). Participants with diagnosed diabetes had a thinner macular retinal nerve fiber layer (mRNFL; -0.58 µm, P < 0.001), photoreceptor layer thickness (-0.94 µm, P < 0.001), and total macular thickness (-1.61 µm, P < 0.001), whereas undiagnosed diabetes participants had a reduced photoreceptor layer thickness (-1.22 µm, P = 0.009) and total macular thickness (-2.26 µm, P = 0.005). Compared to participants without diabetes, those with diabetes had a thinner mRNFL (-0.50 µm, P < 0.001), photoreceptor layer thickness (-0.77 µm, P < 0.001), and total macular thickness (-1.36 µm, P < 0.001).</p>
Conclusions: Participants with higher HbA1c in the normal range had marginally thinner photoreceptor thickness, whereas those with diabetes (including undiagnosed diabetes) had meaningfully thinner retinal sublayer and total macular thickness.</p>
Translational Relevance: We showed that early retinal neurodegeneration occurs in people whose HbA1c levels are below the current diabetes diagnostic threshold; this might impact the management of pre-diabetes individuals.</p>
12 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Diabetes Mellitus
- Diabetic Retinopathy
- Glycated Hemoglobin
- Humans
- Middle Aged
- Reference Values
- Retinal Ganglion Cells
- Tomography, Optical Coherence
- United Kingdom
14 Authors
- Sharon Y. L. Chua
- Paul Welsh
- Zihan Sun
- Konstantinos Balaskas
- Alasdair Warwick
- David Steel
- Sobha Sivaprasad
- Roomasa Channa
- Tony Ko
- Naveed Sattar
- Anthony P. Khawaja
- Paul J. Foster
- Praveen J. Patel
- on behalf of The UK Biobank Eye and Vision Consortium
1 Application
| Application ID | Title |
|---|---|
| 2112 | Automated macular thickness measurements and association with potential risk factors and systemic disease |
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